Abstract
Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.
| Original language | English |
|---|---|
| Pages (from-to) | 9-11 |
| Number of pages | 3 |
| Journal | Trends in Cancer |
| Volume | 11 |
| Issue number | 1 |
| Early online date | 5 Oct 2024 |
| DOIs | |
| State | Published - Jan 2025 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2024 Elsevier Inc.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- HSR
- chromosome bridges
- chromothripsis
- ecDNA
- gene amplification
- micronuclei
Fingerprint
Dive into the research topics of 'Aberrant nuclei with amplified DNA in cancer'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver