Aberrant nuclei with amplified DNA in cancer

Venkata Narasimha Kadali; Ofer Shoshani

doi:10.1016/j.trecan.2024.09.005

Aberrant nuclei with amplified DNA in cancer

Venkata Narasimha Kadali, Ofer Shoshani

Weizmann Institute of Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.

Original language	English
Pages (from-to)	9-11
Number of pages	3
Journal	Trends in Cancer
Volume	11
Issue number	1
Early online date	5 Oct 2024
DOIs	https://doi.org/10.1016/j.trecan.2024.09.005
State	Published - Jan 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Inc.

Keywords

HSR
chromosome bridges
chromothripsis
ecDNA
gene amplification
micronuclei

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.trecan.2024.09.005

Cite this

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abstract = "Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.",

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KW - HSR

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KW - chromothripsis

KW - ecDNA

KW - gene amplification

KW - micronuclei

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Aberrant nuclei with amplified DNA in cancer

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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