A unique sars-cov-2 spike protein p681h variant detected in Israel

on behalf of the Israel National Consortium for SARS-CoV-2 Sequencing

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The routine detection, surveillance, and reporting of novel SARS-CoV-2 variants is crucial, as these threaten to hinder global vaccination efforts. Herein we report a novel local variant with a non-synonymous mutation in the spike (S) protein P681H. This local Israeli variant was not associated with a higher infection rate or higher prevalence. Furthermore, the local variant was successfully neutralized by sera from fully vaccinated individuals at a comparable level to the B.1.1.7 variant and an Israel wild-type strain. While it is not a variant of concern, routine monitoring by sequencing is still required.

Original languageEnglish
Article number616
Issue number6
StatePublished - Jun 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Covid-19
  • SARS-CoV-2
  • Sequencing
  • Variant of concern
  • Virus neutralization


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