Abstract
Herein, we describe a solid-supported stereoselective multicomponent reaction. One of the components, a β-keto-γ-lactam derived from alanine is generated in situ on the solid support and the addition of two equivalents of an aromatic aldehyde and one equivalent of urea generates a spiro-bicyclic γ-lactam bearing three asymmetric carbons in a totally stereoselective manner resulting in a single product. The same reaction performed in solution displayed moderate stereoselectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 747-748 |
| Number of pages | 2 |
| Journal | Synlett |
| Issue number | 5 |
| DOIs | |
| State | Published - 17 Mar 2006 |
Keywords
- Multicomponent reaction
- Solid-phase organic synthesis
- Spiro-heterobicyclic system
- Stereoselectivity
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