A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness

Petra Behnen; Angelo Felline; Antonella Comitato; Maria Teresa Di Salvo; Francesco Raimondi; Sahil Gulati; Shirin Kahremany; Krzysztof Palczewski; Valeria Marigo; Francesca Fanelli

doi:10.1016/j.isci.2018.05.001

A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness

Petra Behnen, Angelo Felline, Antonella Comitato, Maria Teresa Di Salvo, Francesco Raimondi, Sahil Gulati, Shirin Kahremany, Krzysztof Palczewski, Valeria Marigo, Francesca Fanelli

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50 Scopus citations

Abstract

Structural

Original language	English
Pages (from-to)	1-19
Number of pages	19
Journal	iScience
Volume	4
DOIs	https://doi.org/10.1016/j.isci.2018.05.001
State	Published - 29 Jun 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 The Authors

Funding

We acknowledge the CIGS of the University of Modena for providing confocal microscopy assistance. This study was supported by Telethon-Italy grant [ GGP11210 ] and by Fondazione Roma grant (call for proposals 2013 on Retinitis Pigmentosa) to both F.F. and V.M. This research was supported in part by grants from the National Institutes of Health ( EY009339 , EY027283 , and EY024864 to K.P.). K.P. is the John H. Hord Professor of Pharmacology.

Funders	Funder number
Fondazione Roma
National Institutes of Health	EY027283, EY024864, EY009339

Keywords

Biophysics
Protein Folding
Protein Structure Aspects
Structural Biology

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10.1016/j.isci.2018.05.001

Cite this

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title = "A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness",

abstract = "Structural",

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author = "Petra Behnen and Angelo Felline and Antonella Comitato and {Di Salvo}, {Maria Teresa} and Francesco Raimondi and Sahil Gulati and Shirin Kahremany and Krzysztof Palczewski and Valeria Marigo and Francesca Fanelli",

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AU - Behnen, Petra

AU - Felline, Angelo

AU - Comitato, Antonella

AU - Di Salvo, Maria Teresa

AU - Raimondi, Francesco

AU - Gulati, Sahil

AU - Kahremany, Shirin

AU - Palczewski, Krzysztof

AU - Marigo, Valeria

AU - Fanelli, Francesca

PY - 2018/6/29

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AB - Structural

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KW - Protein Folding

KW - Protein Structure Aspects

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A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness

Abstract

Bibliographical note

Funding

Keywords

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