A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness

Petra Behnen, Angelo Felline, Antonella Comitato, Maria Teresa Di Salvo, Francesco Raimondi, Sahil Gulati, Shirin Kahremany, Krzysztof Palczewski, Valeria Marigo, Francesca Fanelli

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Structural

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournaliScience
Volume4
DOIs
StatePublished - 29 Jun 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 The Authors

Funding

We acknowledge the CIGS of the University of Modena for providing confocal microscopy assistance. This study was supported by Telethon-Italy grant [ GGP11210 ] and by Fondazione Roma grant (call for proposals 2013 on Retinitis Pigmentosa) to both F.F. and V.M. This research was supported in part by grants from the National Institutes of Health ( EY009339 , EY027283 , and EY024864 to K.P.). K.P. is the John H. Hord Professor of Pharmacology.

FundersFunder number
Fondazione Roma
National Institutes of HealthEY027283, EY024864, EY009339

    Keywords

    • Biophysics
    • Protein Folding
    • Protein Structure Aspects
    • Structural Biology

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