A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1]heptanes

Alfred Hassner; Anatoly M. Belostotskii

doi:10.1016/0040-4039(95)00051-D

A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1]heptanes

Alfred Hassner
, Anatoly M. Belostotskii

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.

Original language	English
Pages (from-to)	1709-1712
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	10
DOIs	https://doi.org/10.1016/0040-4039(95)00051-D
State	Published - 6 Mar 1995

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS. We thank the Ministry of Science and Technology of Israel for financial support. A National Research Council Award to A. H. is gratefully acknowledged.

Funding

ACKNOWLEDGMENTS. We thank the Ministry of Science and Technology of Israel for financial support. A National Research Council Award to A. H. is gratefully acknowledged.

Funders
Ministry of Science and Technology of Israel

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10.1016/0040-4039(95)00051-D

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title = "A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1]heptanes",

abstract = "Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.",

author = "Alfred Hassner and Belostotskii, \{Anatoly M.\}",

note = "Funding Information: ACKNOWLEDGMENTS. We thank the Ministry of Science and Technology of Israel for financial support. A National Research Council Award to A. H. is gratefully acknowledged.",

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AU - Belostotskii, Anatoly M.

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PY - 1995/3/6

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N2 - Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.

AB - Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.

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A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1]heptanes

Abstract

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