A serological study with monoclonal antibodies to an antigen common to a wide range of bacteria

K. Jensen; J. B. Hertz; J. Samra; C. Magiar; F. S. Larsen; J. Selmer; D. Sompolinsky

doi:10.1111/j.1574-6968.1985.tb00847.x

A serological study with monoclonal antibodies to an antigen common to a wide range of bacteria

K. Jensen, J. B. Hertz, J. Samra, C. Magiar, F. S. Larsen, J. Selmer, D. Sompolinsky

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Three monoclonal antibodies (MCA) against Pseudomonas aeruginosa common antigen (CA) and one MCA against Bordetella pertussis CA were produced. These immunoglobulins were examined by ELISA against extracts of a wide range of Gram-positive and Gram-negative bacteria. No reactions were obtained with Gram-positive organisms. The reaction patterns with Gram-negative organisms were different for each of the monoclonal antibodies and did not follow the accepted taxonomal principles. The results prove that a number of antigen determinants are not shared by CA of different bacteria.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	FEMS Microbiology Letters
Volume	29
Issue number	1-2
DOIs	https://doi.org/10.1111/j.1574-6968.1985.tb00847.x
State	Published - Aug 1985

Bibliographical note

Funding Information:
This study has been supportedin part by a grant from the ResearchF und of Bar Ilan University. We wish to thank Mrs. Zarini Shahnaz for excellents ecretariaal ssistance.

Keywords

Common antigen
cross-reaction
epitope variability

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10.1111/j.1574-6968.1985.tb00847.x

Cite this

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abstract = "Three monoclonal antibodies (MCA) against Pseudomonas aeruginosa common antigen (CA) and one MCA against Bordetella pertussis CA were produced. These immunoglobulins were examined by ELISA against extracts of a wide range of Gram-positive and Gram-negative bacteria. No reactions were obtained with Gram-positive organisms. The reaction patterns with Gram-negative organisms were different for each of the monoclonal antibodies and did not follow the accepted taxonomal principles. The results prove that a number of antigen determinants are not shared by CA of different bacteria.",

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AU - Larsen, F. S.

AU - Selmer, J.

AU - Sompolinsky, D.

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AB - Three monoclonal antibodies (MCA) against Pseudomonas aeruginosa common antigen (CA) and one MCA against Bordetella pertussis CA were produced. These immunoglobulins were examined by ELISA against extracts of a wide range of Gram-positive and Gram-negative bacteria. No reactions were obtained with Gram-positive organisms. The reaction patterns with Gram-negative organisms were different for each of the monoclonal antibodies and did not follow the accepted taxonomal principles. The results prove that a number of antigen determinants are not shared by CA of different bacteria.

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KW - epitope variability

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A serological study with monoclonal antibodies to an antigen common to a wide range of bacteria

Abstract

Bibliographical note

Keywords

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