TY - JOUR
T1 - A Self-Calibrated Single Wavelength Biosensor for Measuring Oxygen Saturation
AU - Katan, Michal
AU - Pearl, Ori
AU - Tzroya, Alon
AU - Duadi, Hamootal
AU - Fixler, Dror
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/3/4
Y1 - 2024/3/4
N2 - Traditional methods for measuring blood oxygen use multiple wavelengths, which produce an intrinsic error due to ratiometric measurements. These methods assume that the absorption changes with the wavelength, but in fact the scattering changes as well and cannot be neglected. We found that if one measures in a specific angle around a cylindrical tissue, called the iso-pathlength (IPL) point, the reemitted light intensity is unaffected by the tissue’s scattering. Therefore, the absorption can be isolated from the scattering, which allows the extraction of the subject’s oxygen saturation. In this work, we designed an optical biosensor for reading the light intensity reemitted from the tissue, using a single light source and multiple photodetectors (PDs), with one of them in the IPL point’s location. Using this bio-device, we developed a methodology to extract the arterial oxygen saturation using a single wavelength light source. We proved this method is not dependent on the light source and is applicable to different measurement locations on the body, with an error of 0.5%. Moreover, we tested thirty-eight males and females with the biosensor under normal conditions. Finally, we show the results of measuring subjects in a hypoxic chamber that simulates extreme conditions with low oxygen.
AB - Traditional methods for measuring blood oxygen use multiple wavelengths, which produce an intrinsic error due to ratiometric measurements. These methods assume that the absorption changes with the wavelength, but in fact the scattering changes as well and cannot be neglected. We found that if one measures in a specific angle around a cylindrical tissue, called the iso-pathlength (IPL) point, the reemitted light intensity is unaffected by the tissue’s scattering. Therefore, the absorption can be isolated from the scattering, which allows the extraction of the subject’s oxygen saturation. In this work, we designed an optical biosensor for reading the light intensity reemitted from the tissue, using a single light source and multiple photodetectors (PDs), with one of them in the IPL point’s location. Using this bio-device, we developed a methodology to extract the arterial oxygen saturation using a single wavelength light source. We proved this method is not dependent on the light source and is applicable to different measurement locations on the body, with an error of 0.5%. Moreover, we tested thirty-eight males and females with the biosensor under normal conditions. Finally, we show the results of measuring subjects in a hypoxic chamber that simulates extreme conditions with low oxygen.
KW - biosensor
KW - light-tissue interaction
KW - oxygen saturation
KW - scattering
KW - tissue diagnostics optics
UR - http://www.scopus.com/inward/record.url?scp=85188829951&partnerID=8YFLogxK
U2 - 10.3390/bios14030132
DO - 10.3390/bios14030132
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C2 - 38534239
AN - SCOPUS:85188829951
SN - 2079-6374
VL - 14
JO - Biosensors
JF - Biosensors
IS - 3
M1 - 132
ER -