A palladium-catalyzed vinylcyclopropane (3 + 2) cycloaddition approach to the Melodinus alkaloids

Alexander F.G. Goldberg, Brian M. Stoltz

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

A palladium-catalyzed (3 + 2) cycloaddition of a vinylcyclopropane and a β-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus alkaloids. The ABCD ring system of the natural product family is prepared in six steps from commercially available materials.

Original languageEnglish
Pages (from-to)4474-4476
Number of pages3
JournalOrganic Letters
Volume13
Issue number16
DOIs
StatePublished - 19 Aug 2011
Externally publishedYes

Funding

FundersFunder number
National Institute of General Medical SciencesR01GM080269

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