A Novel Facial Cream Based on Skin-penetrable Fibrillar Collagen Microparticles

Rachel Lubart; Inbar Yariv; Dror Fixler; Anat Lipovsky

A Novel Facial Cream Based on Skin-penetrable Fibrillar Collagen Microparticles

Rachel Lubart, Inbar Yariv, Dror Fixler, Anat Lipovsky

Hava Zingboim Ltd.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

BACKGROUND:Collagenproteinplaysanotablerolemaintainingfirmskin.Topicalcreamscontainingcollagenfibersarewidelyavailable,buttheir usefulnessisquestionableduetolimitedskinpenetration.Whenappliedinacream,collagendoesnotpenetratetheskinleavingtheskinstructure unaffected.OBJECTIVE:Weformulatedmicronizedcollageninacreambase.Usinghumanskinsamples,wesoughttoinvestigatetheabilityof themicronizedcollagencreamtopenetratehumanskin.METHODS:Particlesizesofmicronizedmarinecollagenwereevaluatedusingelectron microscopy.Opticalprofilometrywasconductedtoevaluateskintopographyandroughness.Theantioxidantactivityofthecollagenwasevaluated usingtheelectronparamagneticresonancetechniquebymeasuringthechangesinfreeradicalproduction.Collagenpenetrationdepthinhuman skinsampleswasmonitoredusinganon-invasiveopticaltechniqueknownasiterativemultiplaneopticalpropertyextraction,whichworksbased onthedetectionoflaserlightphasechangesfollowingthepresenceofcollagenparticlesindeepskinlayers.RESULTS:Accordingtotheelectron microscopy,collagenparticleswerefoundtobeofvarioussizes,thesmallestbeingabout120nmindiameter.Skintopographymeasurements revealedthatthetreatedcollagencreamincreasedskinsmoothnessofthesamples.Ourresultsderivedfromtheiterativemultiplaneopticalproperty extractionindicatedthatmicronizedcollageninacreambasepenetratesboththestratumcorneumandthedeepepidermallayerstowardthe dermis.CONCLUSION:Ourinvestigationsuggeststhatthecollageninthestudiedcreamformulationwasabletopenetratethestratumcoreum and deep epidermal layers in human skin samples.

Original language	English
Pages (from-to)	59-64
Number of pages	6
Journal	Journal of Clinical and Aesthetic Dermatology
Volume	15
Issue number	5
State	Published - 1 May 2022

Bibliographical note

Publisher Copyright:
© 2022 Matrix Medical Communications. All rights reserved.

Funding

FUNDING: The study was sponsored by Hava Zingboim Ltd., Ramat-Gan, Israel. DISCLOSURES: Drs. Lipovsky and Lubart are consultants with Hava Zingboim Ltd. The other authors report no conflicts of interest relevant to the content of this article. CORRESPONDENCE: Rachel Lubart, PhD; Email: [email protected]

Funders	Funder number
Hava Zingboim Ltd.

Keywords

Fibrillar collagen
microparticles
skin penetration

Cite this

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title = "A Novel Facial Cream Based on Skin-penetrable Fibrillar Collagen Microparticles",

abstract = "BACKGROUND:Collagenproteinplaysanotablerolemaintainingfirmskin.Topicalcreamscontainingcollagenfibersarewidelyavailable,buttheir usefulnessisquestionableduetolimitedskinpenetration.Whenappliedinacream,collagendoesnotpenetratetheskinleavingtheskinstructure unaffected.OBJECTIVE:Weformulatedmicronizedcollageninacreambase.Usinghumanskinsamples,wesoughttoinvestigatetheabilityof themicronizedcollagencreamtopenetratehumanskin.METHODS:Particlesizesofmicronizedmarinecollagenwereevaluatedusingelectron microscopy.Opticalprofilometrywasconductedtoevaluateskintopographyandroughness.Theantioxidantactivityofthecollagenwasevaluated usingtheelectronparamagneticresonancetechniquebymeasuringthechangesinfreeradicalproduction.Collagenpenetrationdepthinhuman skinsampleswasmonitoredusinganon-invasiveopticaltechniqueknownasiterativemultiplaneopticalpropertyextraction,whichworksbased onthedetectionoflaserlightphasechangesfollowingthepresenceofcollagenparticlesindeepskinlayers.RESULTS:Accordingtotheelectron microscopy,collagenparticleswerefoundtobeofvarioussizes,thesmallestbeingabout120nmindiameter.Skintopographymeasurements revealedthatthetreatedcollagencreamincreasedskinsmoothnessofthesamples.Ourresultsderivedfromtheiterativemultiplaneopticalproperty extractionindicatedthatmicronizedcollageninacreambasepenetratesboththestratumcorneumandthedeepepidermallayerstowardthe dermis.CONCLUSION:Ourinvestigationsuggeststhatthecollageninthestudiedcreamformulationwasabletopenetratethestratumcoreum and deep epidermal layers in human skin samples.",

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author = "Rachel Lubart and Inbar Yariv and Dror Fixler and Anat Lipovsky",

year = "2022",

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language = "אנגלית",

volume = "15",

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AU - Lubart, Rachel

AU - Yariv, Inbar

AU - Fixler, Dror

AU - Lipovsky, Anat

PY - 2022/5/1

Y1 - 2022/5/1

N2 - BACKGROUND:Collagenproteinplaysanotablerolemaintainingfirmskin.Topicalcreamscontainingcollagenfibersarewidelyavailable,buttheir usefulnessisquestionableduetolimitedskinpenetration.Whenappliedinacream,collagendoesnotpenetratetheskinleavingtheskinstructure unaffected.OBJECTIVE:Weformulatedmicronizedcollageninacreambase.Usinghumanskinsamples,wesoughttoinvestigatetheabilityof themicronizedcollagencreamtopenetratehumanskin.METHODS:Particlesizesofmicronizedmarinecollagenwereevaluatedusingelectron microscopy.Opticalprofilometrywasconductedtoevaluateskintopographyandroughness.Theantioxidantactivityofthecollagenwasevaluated usingtheelectronparamagneticresonancetechniquebymeasuringthechangesinfreeradicalproduction.Collagenpenetrationdepthinhuman skinsampleswasmonitoredusinganon-invasiveopticaltechniqueknownasiterativemultiplaneopticalpropertyextraction,whichworksbased onthedetectionoflaserlightphasechangesfollowingthepresenceofcollagenparticlesindeepskinlayers.RESULTS:Accordingtotheelectron microscopy,collagenparticleswerefoundtobeofvarioussizes,thesmallestbeingabout120nmindiameter.Skintopographymeasurements revealedthatthetreatedcollagencreamincreasedskinsmoothnessofthesamples.Ourresultsderivedfromtheiterativemultiplaneopticalproperty extractionindicatedthatmicronizedcollageninacreambasepenetratesboththestratumcorneumandthedeepepidermallayerstowardthe dermis.CONCLUSION:Ourinvestigationsuggeststhatthecollageninthestudiedcreamformulationwasabletopenetratethestratumcoreum and deep epidermal layers in human skin samples.

AB - BACKGROUND:Collagenproteinplaysanotablerolemaintainingfirmskin.Topicalcreamscontainingcollagenfibersarewidelyavailable,buttheir usefulnessisquestionableduetolimitedskinpenetration.Whenappliedinacream,collagendoesnotpenetratetheskinleavingtheskinstructure unaffected.OBJECTIVE:Weformulatedmicronizedcollageninacreambase.Usinghumanskinsamples,wesoughttoinvestigatetheabilityof themicronizedcollagencreamtopenetratehumanskin.METHODS:Particlesizesofmicronizedmarinecollagenwereevaluatedusingelectron microscopy.Opticalprofilometrywasconductedtoevaluateskintopographyandroughness.Theantioxidantactivityofthecollagenwasevaluated usingtheelectronparamagneticresonancetechniquebymeasuringthechangesinfreeradicalproduction.Collagenpenetrationdepthinhuman skinsampleswasmonitoredusinganon-invasiveopticaltechniqueknownasiterativemultiplaneopticalpropertyextraction,whichworksbased onthedetectionoflaserlightphasechangesfollowingthepresenceofcollagenparticlesindeepskinlayers.RESULTS:Accordingtotheelectron microscopy,collagenparticleswerefoundtobeofvarioussizes,thesmallestbeingabout120nmindiameter.Skintopographymeasurements revealedthatthetreatedcollagencreamincreasedskinsmoothnessofthesamples.Ourresultsderivedfromtheiterativemultiplaneopticalproperty extractionindicatedthatmicronizedcollageninacreambasepenetratesboththestratumcorneumandthedeepepidermallayerstowardthe dermis.CONCLUSION:Ourinvestigationsuggeststhatthecollageninthestudiedcreamformulationwasabletopenetratethestratumcoreum and deep epidermal layers in human skin samples.

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JO - Journal of Clinical and Aesthetic Dermatology

JF - Journal of Clinical and Aesthetic Dermatology

IS - 5

ER -

A Novel Facial Cream Based on Skin-penetrable Fibrillar Collagen Microparticles

Abstract

Bibliographical note

Funding

Keywords

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