A Novel Facial Cream Based on Skin-penetrable Fibrillar Collagen Microparticles

Rachel Lubart, Inbar Yariv, Dror Fixler, Anat Lipovsky

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

BACKGROUND:Collagenproteinplaysanotablerolemaintainingfirmskin.Topicalcreamscontainingcollagenfibersarewidelyavailable,buttheir usefulnessisquestionableduetolimitedskinpenetration.Whenappliedinacream,collagendoesnotpenetratetheskinleavingtheskinstructure unaffected.OBJECTIVE:Weformulatedmicronizedcollageninacreambase.Usinghumanskinsamples,wesoughttoinvestigatetheabilityof themicronizedcollagencreamtopenetratehumanskin.METHODS:Particlesizesofmicronizedmarinecollagenwereevaluatedusingelectron microscopy.Opticalprofilometrywasconductedtoevaluateskintopographyandroughness.Theantioxidantactivityofthecollagenwasevaluated usingtheelectronparamagneticresonancetechniquebymeasuringthechangesinfreeradicalproduction.Collagenpenetrationdepthinhuman skinsampleswasmonitoredusinganon-invasiveopticaltechniqueknownasiterativemultiplaneopticalpropertyextraction,whichworksbased onthedetectionoflaserlightphasechangesfollowingthepresenceofcollagenparticlesindeepskinlayers.RESULTS:Accordingtotheelectron microscopy,collagenparticleswerefoundtobeofvarioussizes,thesmallestbeingabout120nmindiameter.Skintopographymeasurements revealedthatthetreatedcollagencreamincreasedskinsmoothnessofthesamples.Ourresultsderivedfromtheiterativemultiplaneopticalproperty extractionindicatedthatmicronizedcollageninacreambasepenetratesboththestratumcorneumandthedeepepidermallayerstowardthe dermis.CONCLUSION:Ourinvestigationsuggeststhatthecollageninthestudiedcreamformulationwasabletopenetratethestratumcoreum and deep epidermal layers in human skin samples.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalJournal of Clinical and Aesthetic Dermatology
Volume15
Issue number5
StatePublished - 1 May 2022

Bibliographical note

Publisher Copyright:
© 2022 Matrix Medical Communications. All rights reserved.

Keywords

  • Fibrillar collagen
  • microparticles
  • skin penetration

Fingerprint

Dive into the research topics of 'A Novel Facial Cream Based on Skin-penetrable Fibrillar Collagen Microparticles'. Together they form a unique fingerprint.

Cite this