A New Synthesis of Key Intermediates for the Preparation of 5, 6‐DiHETE and Lipoxin A4

A Gigou; J. P Lellouche; J. P Beaucourt; L Toupet; R Grée

A New Synthesis of Key Intermediates for the Preparation of 5, 6‐DiHETE and Lipoxin A4

A Gigou, J. P Lellouche, J. P Beaucourt, L Toupet, R Grée

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The highly diastereoselective osmylation of a C [DOUBLE BOND] C bond in proximity to a complex fragment is the key step in the formation of 2 from the butadiene(tricarbonyl)iron complex 1. The diols 2 can be transformed readily into 3, key intermediates in the synthesis of 5,6-DiHETE and lipoxin A4. R [DOUBLE BOND] SiPh2tBu; R′ [DOUBLE BOND] Me; E [DOUBLE BOND] CO2Me.

Original language	American English
Pages (from-to)	755-757
Journal	Angewandte Chemie International Edition in English
Volume	28
Issue number	6
State	Published - 1989

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abstract = "The highly diastereoselective osmylation of a C [DOUBLE BOND] C bond in proximity to a complex fragment is the key step in the formation of 2 from the butadiene(tricarbonyl)iron complex 1. The diols 2 can be transformed readily into 3, key intermediates in the synthesis of 5,6-DiHETE and lipoxin A4. R [DOUBLE BOND] SiPh2tBu; R′ [DOUBLE BOND] Me; E [DOUBLE BOND] CO2Me.",

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AU - Gigou, A

AU - Lellouche, J. P

AU - Beaucourt, J. P

AU - Toupet, L

AU - Grée, R

PY - 1989

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AB - The highly diastereoselective osmylation of a C [DOUBLE BOND] C bond in proximity to a complex fragment is the key step in the formation of 2 from the butadiene(tricarbonyl)iron complex 1. The diols 2 can be transformed readily into 3, key intermediates in the synthesis of 5,6-DiHETE and lipoxin A4. R [DOUBLE BOND] SiPh2tBu; R′ [DOUBLE BOND] Me; E [DOUBLE BOND] CO2Me.

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JO - Angewandte Chemie International Edition in English

JF - Angewandte Chemie International Edition in English

IS - 6

ER -

A New Synthesis of Key Intermediates for the Preparation of 5, 6‐DiHETE and Lipoxin A4

Abstract

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