A new biomedical device for in vivo multiparametric evaluation of tissue vitality in critical care medicine

Avraham Mayevsky, Assaf Deutsch, Nava Dekel, Eliyahu Pevzner, Alex Jaronkin

Research output: Contribution to journalConference articlepeer-review

8 Scopus citations


Real time Monitoring of mitochondrial function in vivo is a significant factor in the understanding of tissue vitality. Nevertheless a single parameter monitoring device is not appropriate and effective in clinical diagnosis of tissue vitality. Therefore we have developed a multiparameteric monitoring system that monitors, in addition to mitochondrial NADH redox state, tissue microcirculatory blood flow, tissue total back-scattered light as an indication of blood volume and blood oxygenation (HbO2). In the present communication a new device named "CritiView" is described. This device was developed in order to enable real time monitoring of the four parameters from various organs in the body. The main medical application of the CritiView is in critical care medicine of patients hospitalized in the Intensive Care Units (ICUs) and intraoperatively in operating rooms. The physiological basis for our clinical monitoring approach is based on the well known response to the development of body emergency situation, such as shock or trauma. Under such conditions a process of blood flow redistribution will give preference to vital organs (Brain, Heart) neglecting less vital organs (Skin, G-I tract or the urinary system). Under such condition the brain will be hyperperfused and O 2 supply will increase to provide the need of the activated mitochondria. The non-vital organs will be hypoperfused and mitochondrial function will be inhibited leading to energy failure. This differentiation between the two types of organs could be used for the early detection of body deterioration by monitoring of the non-vital organ vitality. A fiber optic sensor was embedded in a Foley catheter, enabling the monitoring of Urethral wall vitality, to serve as an early warning signal of body deterioration.

Original languageEnglish
Article number09
Pages (from-to)60-70
Number of pages11
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2005
EventAdvanced Biomedical and Clinical Diagnostic Systems III - San Jose, CA, United States
Duration: 23 Jan 200526 Jan 2005


  • CritiView
  • Critical Care Medicine
  • Hemoglobin Oxygenation
  • Laser Doppler Flowmetry
  • Mitochondrial function
  • Multiparametric monitoring
  • NADH fluorescence


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