A mutated CCR5 gene may have favorable prognostic implications in MS

Rami Kantor; Mary Bakhanashvili; Anat Achiron

doi:10.1212/01.wnl.0000069921.20347.9e

A mutated CCR5 gene may have favorable prognostic implications in MS

Rami Kantor, Mary Bakhanashvili, Anat Achiron

Research output: Contribution to journal › Article › peer-review

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Abstract

The authors investigated the association between Δ32CCR5, a mutated allele of the chemokine receptor CCR5, and disease progression in 256 patients with multiple sclerosis (MS). The mutated allele frequency in the study cohort was 7.4%, similar to that reported in the general Israeli population. Progression to disability was prolonged in Δ32CCR5 homozygotes and heterozygotes compared with MS patients with the CCR5 wild-type genotype (p < 0.005). Mutated CCR5 allele may be considered a favorable prognostic factor in MS.

Original language	English
Pages (from-to)	238-240
Number of pages	3
Journal	Neurology
Volume	61
Issue number	2
DOIs	https://doi.org/10.1212/01.wnl.0000069921.20347.9e
State	Published - 22 Jul 2003
Externally published	Yes

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AB - The authors investigated the association between Δ32CCR5, a mutated allele of the chemokine receptor CCR5, and disease progression in 256 patients with multiple sclerosis (MS). The mutated allele frequency in the study cohort was 7.4%, similar to that reported in the general Israeli population. Progression to disability was prolonged in Δ32CCR5 homozygotes and heterozygotes compared with MS patients with the CCR5 wild-type genotype (p < 0.005). Mutated CCR5 allele may be considered a favorable prognostic factor in MS.

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A mutated CCR5 gene may have favorable prognostic implications in MS

Abstract

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