TY - JOUR
T1 - A multi-country analysis of COVID-19 hospitalizations by vaccination status
AU - ISARIC Clinical Characterisation Group
AU - Gonçalves, Bronner P.
AU - Jassat, Waasila
AU - Baruch, Joaquín
AU - Hashmi, Madiha
AU - Rojek, Amanda
AU - Dasgupta, Abhishek
AU - Martin-Loeches, Ignacio
AU - Reyes, Luis Felipe
AU - Piubelli, Chiara
AU - Citarella, Barbara Wanjiru
AU - Kartsonaki, Christiana
AU - Lefèvre, Benjamin
AU - López Revilla, José W.
AU - Lunn, Miles
AU - Harrison, Ewen M.
AU - Kraemer, Moritz U.G.
AU - Shrapnel, Sally
AU - Horby, Peter
AU - Bisoffi, Zeno
AU - Olliaro, Piero L.
AU - Merson, Laura
AU - Abdukahil, Sheryl Ann
AU - Jabal, Kamal Abu
AU - Salah, Nashat Abu
AU - Airlangga, Eka
AU - Hssain, Ali Ait
AU - Akwani, Chika
AU - Al Qasim, Eman
AU - Alberti, Angela
AU - Aldabbourosama, Osama
AU - Alessi, Marta
AU - Alex, Beatrice
AU - Al-Fares, Abdulrahman
AU - Aliudin, Jeffrey
AU - Alkahlout, Mohammed
AU - Almasri, Lana
AU - Al-Saba'a, Yousef
AU - Alves, Rita
AU - Cabrita, Joana Alves
AU - Amaral, Maria
AU - Ampaw, Phoebe
AU - Anchan, Aditya John
AU - Angheben, Andrea
AU - Arabi, Yaseen
AU - Arcadipane, Antonio
AU - Archambault, Patrick
AU - Arenz, Lukas
AU - Arora, Rakesh
AU - Ashley, Elizabeth A.
AU - Edelstein, Michael
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/11/10
Y1 - 2023/11/10
N2 - Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section.
AB - Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section.
KW - COVID-19
KW - Translation to population health
KW - comorbidity
KW - descriptive epidemiology
KW - heterogeneity
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85175733841&partnerID=8YFLogxK
U2 - 10.1016/j.medj.2023.08.005
DO - 10.1016/j.medj.2023.08.005
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 37738979
AN - SCOPUS:85175733841
SN - 2666-6359
VL - 4
SP - 797-812.e2
JO - Med
JF - Med
IS - 11
ER -