TY - JOUR
T1 - A mild, room-temperature protection of ketones and aldehydes as 1,3-dioxolanes under basic conditions
AU - Hassner, Alfred
AU - Bandi, Chennakesava Reddy
AU - Panchgalle, Sharad
PY - 2012
Y1 - 2012
N2 - Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N- hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analogue, in the absence of strong protonic acids, and in the presence of base (Et). Acid-sensitive groups such as O-THP, O-TBS, or N-Boc are unaffected.
AB - Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N- hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analogue, in the absence of strong protonic acids, and in the presence of base (Et). Acid-sensitive groups such as O-THP, O-TBS, or N-Boc are unaffected.
KW - aldehydes
KW - ketals
KW - ketones
KW - protecting groups
KW - synthetic methods
UR - http://www.scopus.com/inward/record.url?scp=84868657136&partnerID=8YFLogxK
U2 - 10.1055/s-0032-1317529
DO - 10.1055/s-0032-1317529
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AN - SCOPUS:84868657136
SN - 0936-5214
VL - 23
SP - 2773
EP - 2776
JO - Synlett
JF - Synlett
IS - 19
ER -