A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype

Mariana Schroeder; Mira Jakovcevski; Tamar Polacheck; Maya Lebow; Yonat Drori; Mareen Engel; Shifra Ben-Dor; Alon Chen

doi:10.1016/j.cmet.2017.05.001

A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype

Mariana Schroeder
, Mira Jakovcevski
, Tamar Polacheck
, Maya Lebow
, Yonat Drori
, Mareen Engel
, Shifra Ben-Dor
, Alon Chen

Weizmann Institute of Science
Max Planck Institute of Psychiatry

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Binge eating (BE) is a common aberrant form of eating behavior, characterized by overconsumption of food in a brief period of time. Recurrent episodes of BE constitute the BE disorder, which mostly affects females and is associated with early-life adversities. Here, we show that corticotropin releasing factor (CRF)-induced prenatal stress (PNS) in late gestation predisposes female offspring to BE-like behavior that coincides with hypomethylation of hypothalamic miR-1a and downstream dysregulation of the melanocortin system through Pax7/Pax3. Moreover, exposing the offspring to a methyl-balanced diet during adolescence prevents the dysregulation and predisposition from being triggered. We demonstrate that gestational programming, per se, will not lead to BE-like behavior, but pre-existing alterations due to prenatal programming are revealed only when challenged during adolescence. We provide experimental evidence for long-term epigenetic abnormalities stemming from PNS in predisposing female offspring to BE disorder as well as a potential non-invasive prevention strategy.

Original language	English
Pages (from-to)	1269-1281.e6
Journal	Cell Metabolism
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2017.05.001
State	Published - 6 Jun 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Funding

A.C. is the head of the Max Planck Society–Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics. We thank Mr. Sharon Ovadia for his devoted assistance with animal care; Dr. Jessica Keverne for professional English editing and formatting/scientific input; and Ms. Lisa Tietze for her help with in situ hybridization. This work is supported by: an FP7 Grant from the European Research Council (260463, A.C.); Research Grant from the Israel Science Foundation (1565/15, A.C.); the ERANET Program, supported by the Chief Scientist Office of the Israeli Ministry of Health (A.C.); the BMBF (01KU1501A, A.C.); research support from Roberto and Renata Ruhman (A.C.); research support from Bruno and Simone Licht; I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (grant no. 1916/12 to A.C.); the Nella and Leon Benoziyo Center for Neurological Diseases (A.C.); the Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics (A.C.); the Perlman Family Foundation, founded by Louis L. and Anita M. Perlman (A.C.); the Adelis Foundation (A.C.); and the Irving I. Moskowitz Foundation (A.C.).

Funders	Funder number
Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics
Irving I. Moskowitz Foundation
Nella and Leon Benoziyo Center for Neurological Diseases
Roberto and Renata Ruhman	1916/12
Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics
Achelis Foundation
Seventh Framework Programme
Perlman Family Foundation
European Commission	260463
Bundesministerium für Bildung und Forschung	01KU1501A
Israel Science Foundation	1565/15
Max-Planck-Gesellschaft
Ministry of Health, State of Israel

Keywords

CRF
binge eating
developmental origin of disease hypothesis
developmental programming
dietary manipulations
early-life adversities
eating behavior
eating disorder
methyl balanced diet
prenatal stress

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10.1016/j.cmet.2017.05.001

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title = "A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype",

abstract = "Binge eating (BE) is a common aberrant form of eating behavior, characterized by overconsumption of food in a brief period of time. Recurrent episodes of BE constitute the BE disorder, which mostly affects females and is associated with early-life adversities. Here, we show that corticotropin releasing factor (CRF)-induced prenatal stress (PNS) in late gestation predisposes female offspring to BE-like behavior that coincides with hypomethylation of hypothalamic miR-1a and downstream dysregulation of the melanocortin system through Pax7/Pax3. Moreover, exposing the offspring to a methyl-balanced diet during adolescence prevents the dysregulation and predisposition from being triggered. We demonstrate that gestational programming, per se, will not lead to BE-like behavior, but pre-existing alterations due to prenatal programming are revealed only when challenged during adolescence. We provide experimental evidence for long-term epigenetic abnormalities stemming from PNS in predisposing female offspring to BE disorder as well as a potential non-invasive prevention strategy.",

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author = "Mariana Schroeder and Mira Jakovcevski and Tamar Polacheck and Maya Lebow and Yonat Drori and Mareen Engel and Shifra Ben-Dor and Alon Chen",

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AU - Lebow, Maya

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AU - Ben-Dor, Shifra

AU - Chen, Alon

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A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype

Abstract

Bibliographical note

Funding

Keywords

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