Abstract
Respiratory virus infections are very common. Such infections impose an enormous economic burden and occasionally lead to death. Furthermore, every few decades, respiratory virus pandemics emerge, putting the entire world population at risk. Thus, there is an urgent need to quickly and precisely identify the infecting agent in a clinical setting. However, in many patients with influenza-like symptoms (ILS) the identity of the underlying pathogen remains unknown. In addition, it takes time and effort to individually identify the virus responsible for the ILS. Here, we present a new next-generation sequencing (NGS)-based method that enables rapid and robust identification of pathogens in a pool of clinical samples without the need for specific primers. The method is aimed at rapidly uncovering a potentially common pathogen affecting many samples with an unidentified source of disease.
Original language | English |
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Article number | 2606 |
Journal | Scientific Reports |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - 22 Feb 2019 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019, The Author(s).
Funding
This study was supported in part by a fellowship from the Edmond J. Safra Center for Bioinformatics at Tel-Aviv University [to T.K. and G.L.].
Funders | Funder number |
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Edmond J. Safra Center for Ethics, Harvard University |