A Lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease

Itzhak Mendel; Anat Shoham; Oshrat Propheta-Meiran; Eti Ishai; Gideon Halperin; Erez Feige; Eyal Breitbart

doi:10.1016/j.jneuroim.2010.06.011

A Lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease

Itzhak Mendel
, Anat Shoham
, Oshrat Propheta-Meiran
, Eti Ishai
, Gideon Halperin
, Erez Feige
, Eyal Breitbart

Vascular Biogenics Ltd.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Oxidized phospholipids (Ox-PLs) are generated in abundance at sites of inflammation. Recent studies have indicated that Ox-PLs may also exhibit anti-inflammatory activities. In this study, we investigated the beneficial effect of VB-201, a pure synthetic Ox-PL analog that we synthesized, on the development of a central nervous system (CNS) autoimmune inflammatory disease, in vivo. Oral administration of VB-201 ameliorated the severity of experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) peptide MOG35-55, and restrained the encephalogenicity of MOG35-55-specific T-cells. Our data presents a novel prospect for the role of Ox-PL analogs in CNS inflammatory diseases.

Original language	English
Pages (from-to)	126-135
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	226
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.06.011
State	Published - 14 Sep 2010
Externally published	Yes

Keywords

Experimental autoimmune encephalomyelitis
Oxidized phospholipids
T-cells

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10.1016/j.jneuroim.2010.06.011

Cite this

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abstract = "Oxidized phospholipids (Ox-PLs) are generated in abundance at sites of inflammation. Recent studies have indicated that Ox-PLs may also exhibit anti-inflammatory activities. In this study, we investigated the beneficial effect of VB-201, a pure synthetic Ox-PL analog that we synthesized, on the development of a central nervous system (CNS) autoimmune inflammatory disease, in vivo. Oral administration of VB-201 ameliorated the severity of experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) peptide MOG35-55, and restrained the encephalogenicity of MOG35-55-specific T-cells. Our data presents a novel prospect for the role of Ox-PL analogs in CNS inflammatory diseases.",

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T1 - A Lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease

AU - Mendel, Itzhak

AU - Shoham, Anat

AU - Propheta-Meiran, Oshrat

AU - Ishai, Eti

AU - Halperin, Gideon

AU - Feige, Erez

AU - Breitbart, Eyal

PY - 2010/9/14

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AB - Oxidized phospholipids (Ox-PLs) are generated in abundance at sites of inflammation. Recent studies have indicated that Ox-PLs may also exhibit anti-inflammatory activities. In this study, we investigated the beneficial effect of VB-201, a pure synthetic Ox-PL analog that we synthesized, on the development of a central nervous system (CNS) autoimmune inflammatory disease, in vivo. Oral administration of VB-201 ameliorated the severity of experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) peptide MOG35-55, and restrained the encephalogenicity of MOG35-55-specific T-cells. Our data presents a novel prospect for the role of Ox-PL analogs in CNS inflammatory diseases.

KW - Experimental autoimmune encephalomyelitis

KW - Oxidized phospholipids

KW - T-cells

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A Lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease

Abstract

Keywords

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