A hemin/G-quadruplex acts as an NADH oxidase and NADH peroxidase mimicking DNAzyme

Eyal Golub; Ronit Freeman; Itamar Willner

doi:10.1002/anie.201103853

A hemin/G-quadruplex acts as an NADH oxidase and NADH peroxidase mimicking DNAzyme

Eyal Golub
, Ronit Freeman
, Itamar Willner

Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Abstract

Enzyme impressionist: A DNAzyme consisting of hemin combined with a G-quadruplex was shown to mimic the activity of NADH oxidase under aerobic conditions and of NADH peroxidase under anaerobic conditions. Along with these new biocatalytic activities, the hemin/G-quadruplex complex is also capable of regenerating the biologically important NAD⁺ cofactor in both cycles (see picture).

Original language	English
Pages (from-to)	11710-11714
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	49
DOIs	https://doi.org/10.1002/anie.201103853
State	Published - 2 Dec 2011
Externally published	Yes

Keywords

DNA structures
DNAzymes
G-quadruplexes
enzymes

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10.1002/anie.201103853

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abstract = "Enzyme impressionist: A DNAzyme consisting of hemin combined with a G-quadruplex was shown to mimic the activity of NADH oxidase under aerobic conditions and of NADH peroxidase under anaerobic conditions. Along with these new biocatalytic activities, the hemin/G-quadruplex complex is also capable of regenerating the biologically important NAD+ cofactor in both cycles (see picture).",

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AU - Willner, Itamar

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KW - DNA structures

KW - DNAzymes

KW - G-quadruplexes

KW - enzymes

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A hemin/G-quadruplex acts as an NADH oxidase and NADH peroxidase mimicking DNAzyme

Abstract

Keywords

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