TY - JOUR
T1 - A haplotype relative risk study of the dopamine D4 receptor (DRD4) exon III repeat polymorphism and attention deficit hyperactivity disorder (ADHD)
AU - Eisenberg, Jacques
AU - Zohar, Ada
AU - Mei-Tal, Galit
AU - Steinberg, Avraham
AU - Tartakovsky, Eduardo
AU - Gritsenko, Inga
AU - Nemanov, Lubov
AU - Ebstein, Richard P.
PY - 2000/6/12
Y1 - 2000/6/12
N2 - Attention deficit hyperactivity disorder (ADHD) is a developmental syndrome expressed along three domains: inattention, hyperactive-impulsive, and combined type. Several investigations have recently examined the role of the dopamine DRD4 exon III repeat polymorphism in ADHD. The long 7 repeat allele of this receptor was shown in three family-based studies, but not in one case control design, to be a risk factor for this disorder. We now report an additional family-based study of DRD4 exon III repeat region and ADHD. However, in the current study we fail to observe preferential transmission of the DRD4 exon III long 7 repeat allele, χ2 = 0.142, P < 0.1, df = 1. Nor was any preferential transmission observed when genotypes were compared, χ2 = 0.180, P > 0.1, df = 1. Possible reasons are discussed, especially lack of sufficient power in analying more refined phenotypes, why the current results in contrast to previous findings fail to support a role for the long form of the DRD4 receptor as a putative risk factor for ADHD. (C) 2000 Wiley-Liss, Inc.
AB - Attention deficit hyperactivity disorder (ADHD) is a developmental syndrome expressed along three domains: inattention, hyperactive-impulsive, and combined type. Several investigations have recently examined the role of the dopamine DRD4 exon III repeat polymorphism in ADHD. The long 7 repeat allele of this receptor was shown in three family-based studies, but not in one case control design, to be a risk factor for this disorder. We now report an additional family-based study of DRD4 exon III repeat region and ADHD. However, in the current study we fail to observe preferential transmission of the DRD4 exon III long 7 repeat allele, χ2 = 0.142, P < 0.1, df = 1. Nor was any preferential transmission observed when genotypes were compared, χ2 = 0.180, P > 0.1, df = 1. Possible reasons are discussed, especially lack of sufficient power in analying more refined phenotypes, why the current results in contrast to previous findings fail to support a role for the long form of the DRD4 receptor as a putative risk factor for ADHD. (C) 2000 Wiley-Liss, Inc.
KW - Association
KW - Attention deficit hyperactivity disorder (ADHD)
KW - Complex genetic disease
KW - Dopamine D4 receptor exon III
KW - Haplotype relative risk
KW - Impulsive
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=0034640706&partnerID=8YFLogxK
U2 - 10.1002/1096-8628(20000612)96:3<258::AID-AJMG4>3.0.CO;2-8
DO - 10.1002/1096-8628(20000612)96:3<258::AID-AJMG4>3.0.CO;2-8
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C2 - 10898895
AN - SCOPUS:0034640706
SN - 1552-4841
VL - 96
SP - 258
EP - 261
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 3
ER -
