A fast cardiac gamma camera with dynamic SPECT capabilities: Design, system validation and future potential

Moshe Bocher, Ira M. Blevis, Leonid Tsukerman, Yigal Shrem, Gil Kovalski, Lana Volokh

Research output: Contribution to journalArticlepeer-review

253 Scopus citations

Abstract

Purpose The goal of this study is to present the Discovery NM 530c (DNM), a cardiac SPECT camera, interfacing multi-pinhole collimators with solid-state modules, aiming at slashing acquisition time without jeopardizing quality. DNM resembles PET since it enables 3-D SPECT without detector motion. We further envision how these novel capabilities may help with current and future challenges of cardiac imaging. Methods DNM sensitivity, spatial resolution (SR) and energy resolution (ER), count rate response, cardiac uniformity and cardiac defect contrast were measured and compared to a dedicated cardiac, dual-head standard SPECT (S-SPECT) camera. Results DNM sensitivity was more than threefold higher while SR was notably better. Significantly, SR was the same for 99mTc and 201Tl. ER was improved on DNM and allowed good separation of 99mTc and 123I spectral peaks. Count rate remained linear on DNM up to 612 kcps, while S-SPECT showed severe dead time limitations. Phantom studies revealed comparable uniformity and defect contrast, notwithstanding significantly shorter acquisition time for the DNM. First patient images, including dynamic SPECT, are also presented. Conclusion DNM is raising the bar for expedition and upgrade of practice. It features high sensitivity as well as improved SR, temporal resolution and ER. It enables reduction of acquisition time and fast protocols. Importantly, it is potentially capable of dynamic 3-D acquisition. The new technology is potentially upgradeable and may become a milestone in the evolution of nuclear cardiology as it assumes its key role in molecular imaging of the heart.

Original languageEnglish
Pages (from-to)1887-1902
Number of pages16
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume37
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Cardiac gamma camera
  • Discovery NM 530c
  • Myocardial perfusion scintigraphy
  • Single photon emission computed tomography

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