A facile synthesis of (15N2) malononitrile

Avital Laxer, Bilha Fischer

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The first synthesis of doubly 15N-labelled malononitrile is described and its spectral properties are provided. A highly pure, (15N2) malononitrile is obtained in a facile and simple two-step synthesis which include reaction of diethyl malonate with 25% 15NH4OH at room temperature overnight to form (15N2)-malonodiamide in 84% yield, and dehydration of the latter by POCl3 in acetonitrile to (15N2) malononitrile (75%). The choice of reagents, and simple solutions for work-up, are discussed.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number1
StatePublished - 2000


  • (N) malononitrile
  • (N)-malonodiamide


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