A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention

Elad Lax; Gal Warhaftig; David Ohana; Rachel Maayan; Yael Delayahu; Paola Roska; Alexander M. Ponizovsky; Abraham Weizman; Gal Yadid; Moshe Szyf

doi:10.3389/fnmol.2018.00322

A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention

Elad Lax, Gal Warhaftig, David Ohana, Rachel Maayan, Yael Delayahu, Paola Roska, Alexander M. Ponizovsky, Abraham Weizman, Gal Yadid, Moshe Szyf

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.

Original language	English
Article number	322
Journal	Frontiers in Molecular Neuroscience
Volume	11
DOIs	https://doi.org/10.3389/fnmol.2018.00322
State	Published - 10 Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 Lax, Warhaftig, Ohana, Maayan, Delayahu, Roska, Ponizovsky, Weizman, Yadid and Szyf.

Keywords

DNA methylation
Dehydroepiandrosterone (DHEA)
Drug abuse
Drug-addiction
Genome-wide analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fnmol.2018.00322

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abstract = "Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.",

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AU - Ohana, David

AU - Maayan, Rachel

AU - Delayahu, Yael

AU - Roska, Paola

AU - Ponizovsky, Alexander M.

AU - Weizman, Abraham

AU - Yadid, Gal

AU - Szyf, Moshe

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A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention

Abstract

Bibliographical note

Keywords

UN SDGs

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