A contemporary review on - Polymer stereocomplexes and its biomedical application

Muthupandian Saravanan, Abraham J. Domb

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

Nanomedicine is the most emerging, multidisciplinary field of research that is gaining popularity in recent years. Nanomedicine encompasses medical applications of nanomaterials, nanoelectronic biosensors including future applications of molecular nanotechnology. Nanomedical approaches to drug delivery, wound healing and treatment of certain diseases center on developing nanoscale particles such as sterocomplexed polymers and hydrogels or similar molecules to improve drug bioavailability. These polymers are biodegradable, bioactive, biocompatible and their strong interactions with the drug help in sustained release of the drug for longer periods. The formulation of these drugs and sterocomplexed polymers to be used as controlled drug delivery system are discussed in this tutorial review. Polymer stereocomplexes have a great promise in sustained delivery of human growth hormone, insulin, Leuprolide, Bupivacaine, Dexamethanosone, Doxorubicin, Haloperidol and vaccines. Various novel ideas of drug delivery into eye, uterus (birth control), targeted cancer therapy and brain diseases (Parkinson's and Alzheimer's diseases).

Original languageEnglish
Pages (from-to)81-96
Number of pages16
JournalEuropean Journal of Nanomedicine
Volume5
Issue number2
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • Biocompatible
  • Biodegradable polymer
  • Controlled drug delivery
  • Nanomedicine
  • Polymer stereocomplex

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