Abstract
As cardiovascular diseases continue to be the leading cause of death worldwide, groundbreaking research is being conducted to mitigate their effects. This review looks into the potential of small nucleolar RNAs (snoRNAs) and the opportunity to use these molecular agents as therapeutic biomarkers for cardiovascular issues specific to the heart. Through an investigation of snoRNA biogenesis, functionality, and roles in cardiovascular diseases, this review relates our past and present knowledge of snoRNAs to the current scientific literature. Considering the initial discovery of snoRNAs and the studies thereafter analyzing the roles of snoRNAs in disease, we look forward to uncovering many other noncanonical functions that could lead researchers closer to finding preventive and curative solutions for cardiovascular diseases.
| Original language | English |
|---|---|
| Article number | 102087 |
| Journal | Molecular Therapy Nucleic Acids |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - 12 Mar 2024 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2023 The Authors
Funding
This work was partially supported by American Heart Association Innovative project Award 23IPA105444 , NIH grant HL164794 , and startup funds from the Temple University Medical Center to V.N.S.G. A.K.R. is supported by the American Heart Association-Post Doctoral Fellowship grant 2021AHA000POST000217114 . All of the figures were created and published using BioRender.com .
| Funders | Funder number |
|---|---|
| Temple University Medical Center | |
| National Institutes of Health | HL164794 |
| American Heart Association | 23IPA105444, 2021AHA000POST000217114 |
Keywords
- C/D box snoRNA
- H/ACA box snoRNA
- MT: Noncoding RNAs
- RNA modification
- cardiovascular diseases
- noncoding RNAs
- scaRNA
