A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy

Nichal Gentilal; Ariel Naveh; Tal Marciano; Zeev Bomzon; Yevgeniy Telepinsky; Yoram Wasserman; Pedro Cavaleiro Miranda

doi:10.1109/embc46164.2021.9630071

A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy

Nichal Gentilal, Ariel Naveh, Tal Marciano, Zeev Bomzon, Yevgeniy Telepinsky, Yoram Wasserman, Pedro Cavaleiro Miranda

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

In this work we investigated the relation between the power density in the tumor and the maximum temperature reached in the scalp during TTFields treatment for glioblastoma. We used a realistic head model to perform the simulations in COMSOL Multiphysics and we solved Pennes' equation to obtain the temperature distribution. Our results indicate that there might be a linear relation between these two quantities and that TTFields are safe from a thermal point of view.

Original language	English
Title of host publication	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4192-4195
Number of pages	4
ISBN (Electronic)	9781728111797
DOIs	https://doi.org/10.1109/embc46164.2021.9630071
State	Published - Nov 2021
Externally published	Yes
Event	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 - Virtual, Online, Mexico Duration: 1 Nov 2021 → 5 Nov 2021

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2021-January
ISSN (Print)	1557-170X

Conference

Conference	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Country/Territory	Mexico
City	Virtual, Online
Period	1/11/21 → 5/11/21

Bibliographical note

Publisher Copyright:
© 2021 IEEE.

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10.1109/embc46164.2021.9630071

Cite this

Gentilal, N., Naveh, A., Marciano, T., Bomzon, Z., Telepinsky, Y., Wasserman, Y., & Miranda, P. C. (2021). A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 (pp. 4192-4195). (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2021-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/embc46164.2021.9630071

Gentilal, Nichal ; Naveh, Ariel ; Marciano, Tal et al. / A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy. 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 4192-4195 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy",

abstract = "In this work we investigated the relation between the power density in the tumor and the maximum temperature reached in the scalp during TTFields treatment for glioblastoma. We used a realistic head model to perform the simulations in COMSOL Multiphysics and we solved Pennes' equation to obtain the temperature distribution. Our results indicate that there might be a linear relation between these two quantities and that TTFields are safe from a thermal point of view.",

author = "Nichal Gentilal and Ariel Naveh and Tal Marciano and Zeev Bomzon and Yevgeniy Telepinsky and Yoram Wasserman and Miranda, {Pedro Cavaleiro}",

note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 ; Conference date: 01-11-2021 Through 05-11-2021",

year = "2021",

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doi = "10.1109/embc46164.2021.9630071",

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Gentilal, N, Naveh, A, Marciano, T, Bomzon, Z, Telepinsky, Y, Wasserman, Y & Miranda, PC 2021, A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy. in 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2021-January, Institute of Electrical and Electronics Engineers Inc., pp. 4192-4195, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021, Virtual, Online, Mexico, 1/11/21. https://doi.org/10.1109/embc46164.2021.9630071

A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy. / Gentilal, Nichal; Naveh, Ariel; Marciano, Tal et al.
43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 4192-4195 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2021-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Telepinsky, Yevgeniy

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Gentilal N, Naveh A, Marciano T, Bomzon Z, Telepinsky Y, Wasserman Y et al. A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 4192-4195. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/embc46164.2021.9630071

A computational study of the relation between the power density in the tumor and the maximum temperature in the scalp during Tumor Treating Fields (TTFields) therapy

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