TY - JOUR
T1 - A comparative nutritional and phytochemical profile along with in-vitro anti-fungal and anti-oxidant activities of snow mountain garlic with normal garlic
AU - Kaur, Bhupinder
AU - Kumar, Nitish
AU - Sharma, Rajni
AU - Shukla, Shardulya
AU - Patel, Manoj K.
AU - Kumar, Raj
AU - Singh, Mohan
AU - Chaurasia, Om Prakash
AU - Chopra, Kanwaljit
AU - Saxena, Shweta
N1 - Publisher Copyright:
© The Author(s) under exclusive licence to Society for Plant Research 2025.
PY - 2025
Y1 - 2025
N2 - Snow Mountain Garlic (SMG) is a mountainous wild species of Allium, popular for its medicinal merits and phytoactive components in the Himalayan and Amchi herbal remedy system. The present study aimed to study the phytochemistry of its extract(s) and compare their in-vitro antifungal and antioxidant efficacies in comparison to normal garlic (NG). In this study, via various standard analytical techniques, i.e., HP-TLC, GC-MS/MS; nutritional and secondary metabolite profiles were established. Additionally, in-vitro antioxidant and agar well diffusion susceptibility assays were conducted to investigate the bioactivity. The enrichment of glycosides, saponins, carbohydrates, folic acid, and selenium was observed in SMG compared to NG. Further, fractions of both the garlic showed a significant distinction in their phytochemical composition. Against NG, SMG showed a significantly high amount of fatty aldehyde, fatty acids, and fatty acid methyl ester, along with a higher flavonoid content in the aqueous extract and ethyl acetate fraction (43.64 ± 1.42 and 195.55 ± 4.56 mg RTHE/100 mg of dry extract respectively). The ethyl acetate fraction of SMG showed the largest zone of inhibition, i.e., 24 ± 1, 26 ± 0, and 20.33 ± 0.58 mm against clinical isolates of Candida species viz. C. albicans, C. glabrata, and C. tropicalis, respectively, and was remarkably better than that of extract(s)/fraction(s) of NG. With this report, our group provides an in-vitro validation of the anti-infective and antioxidant merits of SMG along with its nutritional and phytochemical fingerprinting in comparison with NG to endorse its pharmacological utility as a high mountain folk medicine.
AB - Snow Mountain Garlic (SMG) is a mountainous wild species of Allium, popular for its medicinal merits and phytoactive components in the Himalayan and Amchi herbal remedy system. The present study aimed to study the phytochemistry of its extract(s) and compare their in-vitro antifungal and antioxidant efficacies in comparison to normal garlic (NG). In this study, via various standard analytical techniques, i.e., HP-TLC, GC-MS/MS; nutritional and secondary metabolite profiles were established. Additionally, in-vitro antioxidant and agar well diffusion susceptibility assays were conducted to investigate the bioactivity. The enrichment of glycosides, saponins, carbohydrates, folic acid, and selenium was observed in SMG compared to NG. Further, fractions of both the garlic showed a significant distinction in their phytochemical composition. Against NG, SMG showed a significantly high amount of fatty aldehyde, fatty acids, and fatty acid methyl ester, along with a higher flavonoid content in the aqueous extract and ethyl acetate fraction (43.64 ± 1.42 and 195.55 ± 4.56 mg RTHE/100 mg of dry extract respectively). The ethyl acetate fraction of SMG showed the largest zone of inhibition, i.e., 24 ± 1, 26 ± 0, and 20.33 ± 0.58 mm against clinical isolates of Candida species viz. C. albicans, C. glabrata, and C. tropicalis, respectively, and was remarkably better than that of extract(s)/fraction(s) of NG. With this report, our group provides an in-vitro validation of the anti-infective and antioxidant merits of SMG along with its nutritional and phytochemical fingerprinting in comparison with NG to endorse its pharmacological utility as a high mountain folk medicine.
KW - Anti-candida activity
KW - Antioxidant
KW - Normal garlic
KW - Phytocompounds profile
KW - Snow mountain garlic
UR - http://www.scopus.com/inward/record.url?scp=85219024732&partnerID=8YFLogxK
U2 - 10.1007/s42535-025-01184-3
DO - 10.1007/s42535-025-01184-3
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AN - SCOPUS:85219024732
SN - 0970-4078
JO - Vegetos
JF - Vegetos
ER -