A case of prolonged allograft survival after a short-term treatment with cyclosporin A in a child with aplastic anemia

A child with severe idiopathic aplastic anemia was treated with cyclosporin A for 16 weeks. Skin necrosis occurred on the dorsum of the left hand; mucormycosis was cultured. An underlying osteomyelitis was suspected. The defect was covered with live donor allograft skin, since it was feared that there would be considerable bleeding from autograft donor sites. There was no evidence of graft rejection, either during treatment or in the year after cyclosporin A was withdrawn. No evidence of mucormycosis or osteomyelitis was seen subsequent to skin grafting.