A brief review of single-cell transcriptomic technologies

Tomer Kalisky; Sarit Oriel; Tali Hana Bar-Lev; Nissim Ben-Haim; Ariel Trink; Yishay Wineberg; Itamar Kanter; Shlomit Gilad; Saumyadipta Pyne

doi:10.1093/bfgp/elx019

A brief review of single-cell transcriptomic technologies

Tomer Kalisky
, Sarit Oriel
, Tali Hana Bar-Lev
, Nissim Ben-Haim
, Ariel Trink
, Yishay Wineberg
, Itamar Kanter
, Shlomit Gilad
, Saumyadipta Pyne

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

In recent years, there has been an effort to develop new technologies formeasuring gene expression and sequence information fromthousands of individual cells. Large data sets that were obtained using these 'single cell' technologies have allowed scientists to address fundamental questions in biomedicine ranging fromstems cells and development to cancer and immunology. Here, we provide a brief review of recent developments in single-cell technology. Our intention is to provide a quick background for newcomers to the field as well as a deeper description of some of the leading technologies to date.

Original language	English
Pages (from-to)	64-76
Number of pages	13
Journal	Briefings in Functional Genomics
Volume	17
Issue number	1
DOIs	https://doi.org/10.1093/bfgp/elx019
State	Published - 1 Jan 2018

Bibliographical note

Publisher Copyright:
© The Author 2017.

Funding

T.K., S.O., T.H.B.L, N.B.H, A.T., Y.W., and I.K. are supported by the Israel Science Foundation (ICORE no. 1902/12 and Grants no. 1634/13 and 2017/13), the Israel Cancer Association (Grant no. 20150911), the Israel Ministry of Health (Grant no. 3-10146), and the EU-FP7 (Marie Curie International Reintegration Grant no. 618592). S.P. is supported by Ramalingaswami Fellowship from the Department of Biotechnology, India.

Funders	Funder number
EU-FP7	618592
Israel Ministry of Health	3-10146
Department of Biotechnology, Ministry of Science and Technology, India
Israel Cancer Association	20150911
Israel Science Foundation	2017/13, 1634/13, 1902/12

Keywords

Genomics
RNA sequencing
Single-cell technologies

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/bfgp/elx019

Cite this

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A brief review of single-cell transcriptomic technologies

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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