A bis(phosphine)-modified peptide ligand for stable and luminescent quantum dots in aqueous media

Michael E. Jung, Michael Trzoss, James M. Tsay, Shimon Weiss

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We describe a new class of ligands for semiconductor nanoparticles (quantum dots = QDs), which bind well and allow for their facile dissolution in aqueous solution. As a proof of principle, we have designed and synthesized a novel bis(phosphine)-modified peptide (BPMP) and shown that it has the ability to solubilize quantum dots in aqueous media. We further showed that the corresponding phosphine oxide derivatives of these new ligands are less good at solubilizing the quantum dots. These new bis(phosphine)-modified peptide ligands are easy to prepare and may well replace thiol-containing binding sequences in functionalized peptides for quantum dot coating, potentially resulting in quantum dots with higher quantum yields.

Original languageEnglish
Article numberSS-2013-M0320-OP
Pages (from-to)2426-2430
Number of pages5
JournalSynthesis (Germany)
Volume45
Issue number17
DOIs
StatePublished - 1 Sep 2013
Externally publishedYes

Keywords

  • bis(phosphine)-modified peptides
  • ligands
  • nanoparticles
  • quantum dot stabilization
  • quantum dots

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