TY - JOUR
T1 - 4NQO-induced rat tongue carcinoma
T2 - An ultrastructural study
AU - Vered, Marilena
AU - Polak-Charcon, Sylvie
AU - Babushkin, Tania
AU - Dayan, Dan
PY - 2008/10
Y1 - 2008/10
N2 - The 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinoma, in which the carcinogen is administered systemically in drinking water, is the most comparable animal model to the development of human oral carcinoma. This is the first study to report the ultrastructural changes in this model. The most significant changes were observed in the carcinoma cells at the invasion front and included unique modifications in the basal lamina, presence of micropinocytotic vesicles (plasmalemmal caveolae), and emergence of cytoplasmic microfilaments featuring a parallel arrangement. The microfilaments, in both appearance and organization, were consistent with contractile microfilaments. These observations may be the morphological reflection of the phenotypic modifications occurring within the carcinoma cells, approaching smooth muscle differentiation.
AB - The 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinoma, in which the carcinogen is administered systemically in drinking water, is the most comparable animal model to the development of human oral carcinoma. This is the first study to report the ultrastructural changes in this model. The most significant changes were observed in the carcinoma cells at the invasion front and included unique modifications in the basal lamina, presence of micropinocytotic vesicles (plasmalemmal caveolae), and emergence of cytoplasmic microfilaments featuring a parallel arrangement. The microfilaments, in both appearance and organization, were consistent with contractile microfilaments. These observations may be the morphological reflection of the phenotypic modifications occurring within the carcinoma cells, approaching smooth muscle differentiation.
KW - 4NQO
KW - Microfilaments
KW - Smooth muscle differentiation
KW - Tongue carcinoma
UR - http://www.scopus.com/inward/record.url?scp=55049099327&partnerID=8YFLogxK
U2 - 10.1080/01913120802034645
DO - 10.1080/01913120802034645
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C2 - 18958793
AN - SCOPUS:55049099327
SN - 0191-3123
VL - 32
SP - 199
EP - 205
JO - Ultrastructural Pathology
JF - Ultrastructural Pathology
IS - 5
ER -