3D shortcuts to gene regulation

Ofir Hakim, Myong Hee Sung, Gordon L. Hager

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Recent technologies have allowed high-resolution genome-wide binding profiles of numerous transcription factors and other proteins. A widespread observation has emerged from studies in diverse mammalian systems: most binding events are located at great distances from gene promoters. It is becoming apparent that the traditional one-dimensional view of gene regulation via the proximal cis regulatory elements is over-simplified. True proximity and functional relevance can be revealed by studying the three-dimensional structure of the genome packaged inside the nucleus. Thus the spatial architecture of the genome has attracted a lot of interest and has intensified its significance in modern cell biology. Here we discuss current methods, concepts, and controversies in this rapidly evolving field.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalCurrent Opinion in Cell Biology
Issue number3
StatePublished - Jun 2010
Externally publishedYes


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