3D genome organisation in Drosophila

Charlotte Moretti, Isabelle Stévant, Yad Ghavi-Helm

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Ever since Thomas Hunt Morgan's discovery of the chromosomal basis of inheritance by using Drosophila melanogaster as a model organism, the fruit fly has remained an essential model system in studies of genome biology, including chromatin organisation. Very much as in vertebrates, in Drosophila, the genome is organised in territories, compartments and topologically associating domains (TADs). However, these domains might be formed through a slightly different mechanism than in vertebrates due to the presence of a large and potentially redundant set of insulator proteins and the minor role of dCTCF in TAD boundary formation. Here, we review the different levels of chromatin organisation in Drosophila and discuss mechanisms and factors that might be involved in TAD formation. The dynamics of TADs and enhancer-promoter interactions in the context of transcription are covered in the light of currently conflicting results. Finally, we illustrate the value of polymer modelling approaches to infer the principles governing the three-dimensional organisation of the Drosophila genome.

Original languageEnglish
Pages (from-to)92-100
Number of pages9
JournalBriefings in Functional Genomics
Volume19
Issue number2
DOIs
StatePublished - 23 Mar 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected]

Funding

This work was financially supported by an European Research Council starting grant (759708), a grant from the Ecole Normale Supérieure de Lyon to Y.G.-H. and a Fondation ARC pour la recherche sur le cancer fellowship (PDF20171206672) to C.M. This work was financially supported by an European Research Council starting grant (759708), a grant from the Ecole Normale Sup?rieure de Lyon to Y.G.-H. and a Fondation ARC pour la recherche sur le cancer fellowship (PDF20171206672) to C.M.

FundersFunder number
Ecole Normale Sup?rieure de Lyon
Horizon 2020 Framework Programme759708
European Research Council
Fondation ARC pour la Recherche sur le CancerPDF20171206672
École normale supérieure de Lyon

    Keywords

    • Chromatin organisation
    • Drosophila
    • Topologically associating domains
    • Transcription

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