Alkylations of Enols and Enolates

B. M. Stoltz, N. B. Bennett, D. C. Duquette, A. F.G. Goldberg, Y. Liu, M. B. Loewinger, C. M. Reeves

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

39 Scopus citations

Abstract

This chapter discusses the C-alkylation of enolates and enols and deals with all aspects of this venerable transformation, from early examples of bond formation, to more stereochemically rich reactions, to the most modern catalytic enantioselective processes. Although not exhaustively comprehensive, it is our intuition that readers of this chapter will emerge with a deep understanding of enol/enolate alkylation technologies from both fundamental and practical vantage points.

Original languageEnglish
Title of host publicationCarbon-Carbon Bond Formation
PublisherElsevier Ltd.
Pages1-55
Number of pages55
Volume3
ISBN (Print)9780080977430
DOIs
StatePublished - Feb 2014
Externally publishedYes

Keywords

  • Alkylation
  • Allylic alkylation
  • Chiral auxiliaries
  • Enolate
  • Phase transfer catalysis
  • Phosphazene superbases
  • Transition metal catalysis

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