Abstract
This chapter discusses the C-alkylation of enolates and enols and deals with all aspects of this venerable transformation, from early examples of bond formation, to more stereochemically rich reactions, to the most modern catalytic enantioselective processes. Although not exhaustively comprehensive, it is our intuition that readers of this chapter will emerge with a deep understanding of enol/enolate alkylation technologies from both fundamental and practical vantage points.
Original language | English |
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Title of host publication | Carbon-Carbon Bond Formation |
Publisher | Elsevier Ltd. |
Pages | 1-55 |
Number of pages | 55 |
Volume | 3 |
ISBN (Print) | 9780080977430 |
DOIs | |
State | Published - Feb 2014 |
Externally published | Yes |
Keywords
- Alkylation
- Allylic alkylation
- Chiral auxiliaries
- Enolate
- Phase transfer catalysis
- Phosphazene superbases
- Transition metal catalysis