TY - PAT
T1 - 2-amino-N'-benzylideneacetohydrazides and Derivatives for the Management of CFTR Protein Mediated Diseases
AU - Sendrowitz, H.
AU - McCarty, N.
AU - Cui, G.
AU - Khazanov, N.
PY - 2020
Y1 - 2020
N2 - This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 2-amino-N′-benzylidene-acetohydrazide compound or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N′-benzylidene-acetohydrazide compound is ((E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide; or (E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide.
AB - This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 2-amino-N′-benzylidene-acetohydrazide compound or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N′-benzylidene-acetohydrazide compound is ((E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide; or (E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide.
UR - http://scholar.google.com/scholar?num=3&hl=en&lr=&q=allintitle%3A%202-amino-N%27-benzylideneacetohydrazides%20and%20Derivatives%20for%20the%20Management%20of%20CFTR%20Protein%20Mediated%20Diseases%2C%20author%3ASendrowitz%20OR%20author%3AMcCarty%20OR%20author%3ACui%20OR%20author%3ASenderowitz%20OR%20author%3AKhazanov&as_ylo=2018&as_yhi=&btnG=Search&as_vis=0
UR - https://patents.justia.com/patent/20200138752
M3 - Patent
ER -