β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

David Enshell-Seijffers, Catherine Lindon, Mariko Kashiwagi, Bruce A. Morgan

Research output: Contribution to journalArticlepeer-review

301 Scopus citations

Abstract

The activity of keratinocytes in the hair follicle is regulated by signals from a specialized mesenchymal niche, the dermal papilla (DP). Here, mice expressing cre recombinase in the DP were developed to probe the interaction between follicular keratinocytes and the DP in vivo. Inactivation of the β-catenin gene within DP of fully developed hair follicles results in dramatically reduced proliferation of the progenitors and their progeny that generate the hair shaft, and, subsequently, premature induction of the destructive phase of the hair cycle. It also prevents regeneration of the cycling follicle from stem cells. Gene expression analysis reveals that β-catenin activity in the DP regulates signaling pathways, including FGF and IGF, that can mediate the DP's inductive effects. This study reveals a signaling loop that employs Wnt/β-catenin signaling in both epithelial progenitor cells and their mesenchymal niche to govern and coordinate the interactions between these compartments to guide hair morphogenesis.

Original languageEnglish
Pages (from-to)633-642
Number of pages10
JournalDevelopmental Cell
Volume18
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Bibliographical note

Funding Information:
We thank Eleanor Wu and Ying Zheng for technical assistance and F. Costantini and G. Martin for providing mice. This work was supported by grants from the National Institute of Arthritis, Musculoskeletal and Skin Diseases (R01AR055256, B.A.M.), and Shiseido, Ltd. (B.A.M.).

Keywords

  • Devbio
  • Stemcell

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