β,γ-Dihalopropylamines. I. 1-amino-2,3-dichlor opropane s and 1,4-diamino-2,3-dichlorobutanes

Norman H. Cromwell, Alfred Hassner

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Abstract

The hydrochlorides of 1-piperidino, 1-dimethylamino and 1-dibenzylamino-2,3-dichloropropane have been prepared by chlorine addition to the corresponding allylamine hydrochlorides. Compared with 2-piperidino-1,3-dichloropropane hydrochloride, the 1-piperidino-2,3-dichloropropane hydrochloride is thermally more stable. These compounds react slowly with piperidine to produce triaminopropanes. The dihydrochlorides of 1,4-dipiperidino, 1,4-bis-dimethylamino and 1,4-dimorpholino- 2,3-dichlorobutane have been prepared by chlorine addition to the corresponding 1,4-diaminobutene dihydrochlorides. These compounds have been synthesized for pharmacological testing as anti-tumor agents, etc.

Original languageEnglish
Pages (from-to)1568-1572
Number of pages5
JournalJournal of the American Chemical Society
Volume77
Issue number6
DOIs
StatePublished - 1955
Externally publishedYes

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