TY - JOUR
T1 - β,γ-Dihalopropylamines. I. 1-amino-2,3-dichlor opropane s and 1,4-diamino-2,3-dichlorobutanes
AU - Cromwell, Norman H.
AU - Hassner, Alfred
PY - 1955
Y1 - 1955
N2 - The hydrochlorides of 1-piperidino, 1-dimethylamino and 1-dibenzylamino-2,3-dichloropropane have been prepared by chlorine addition to the corresponding allylamine hydrochlorides. Compared with 2-piperidino-1,3-dichloropropane hydrochloride, the 1-piperidino-2,3-dichloropropane hydrochloride is thermally more stable. These compounds react slowly with piperidine to produce triaminopropanes. The dihydrochlorides of 1,4-dipiperidino, 1,4-bis-dimethylamino and 1,4-dimorpholino- 2,3-dichlorobutane have been prepared by chlorine addition to the corresponding 1,4-diaminobutene dihydrochlorides. These compounds have been synthesized for pharmacological testing as anti-tumor agents, etc.
AB - The hydrochlorides of 1-piperidino, 1-dimethylamino and 1-dibenzylamino-2,3-dichloropropane have been prepared by chlorine addition to the corresponding allylamine hydrochlorides. Compared with 2-piperidino-1,3-dichloropropane hydrochloride, the 1-piperidino-2,3-dichloropropane hydrochloride is thermally more stable. These compounds react slowly with piperidine to produce triaminopropanes. The dihydrochlorides of 1,4-dipiperidino, 1,4-bis-dimethylamino and 1,4-dimorpholino- 2,3-dichlorobutane have been prepared by chlorine addition to the corresponding 1,4-diaminobutene dihydrochlorides. These compounds have been synthesized for pharmacological testing as anti-tumor agents, etc.
UR - http://www.scopus.com/inward/record.url?scp=0009611317&partnerID=8YFLogxK
U2 - 10.1021/ja01611a049
DO - 10.1021/ja01611a049
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AN - SCOPUS:0009611317
SN - 0002-7863
VL - 77
SP - 1568
EP - 1572
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 6
ER -