Research output per year
Research output per year
Research activity per year
Yoav Paas is a neuroscientist at the Mina and Everard Goodman Faculty of Life Sciences of the Bar-Ilan University in Israel. He received his PhD in neurobiology from the Weizmann Institute of Science, for his research on ionotropic glutamate receptors. At the end of 1996, he started his postdoctoral research at the Pasteur Institute in Paris, where he worked on the nicotinic acetylcholine receptor. He moved to the Faculty of Life Sciences at the Bar-Ilan University in October 2006, where he established the Laboratory of Ion Channels. He is a Review Editor for Frontiers in Molecular Neuroscience. His areas of interest include neuroscience, physiology, and biophysics and pharmacology of ion channels.
Research: Biophysics, Pharmacology, and Structure of Ion Channels
Our laboratory is interested in Cys-loop receptors. The latter are ionic channels activated by neurotransmitters such as acetylcholine, serotonin, glycine, gamma-aminobutyric acid (GABA), histamine, or glutamate. Cys-loop receptors play a key role in our day-to-day functions, from body motions to cognitive processes, as they mediate and regulate fast transmission of chemo-electric signals throughout the nervous system. Being physiologically important, impairment of Cys-loop receptor activity leads to neurological disorders such as epilepsy, irritable bowel syndrome, addiction to nicotine, exaggerated startle responses, and other disorders.
More specifically, we focus on molecular aspects of Cys-loop receptors at high resolution, as follows:
1. Biophysical aspects that include mechanisms of channel gating, mechanisms of ionic permeation and ionic selectivity, and mechanisms underlying coupling of the neurotransmitter-binding site to channel activity.
2. Pharmacological aspects that include mechanisms of ligand recognition and rational drug design.
The research in our laboratory employs the following techniques: recombinant DNA technology, protein engineering, protein purification, protein crystallization, ligand-binding assays, electrophysiological recordings of ionic currents, and computer-assisted structural modeling.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
PhD, Weizmann Institute of Science
Jul 1991 → Aug 1996
Award Date: 1 Aug 1996
Master's Degree, Weizmann Institute of Science
Oct 1987 → Feb 1990
Award Date: 1 Feb 1990
Bachelor, Tel Aviv University
Oct 1984 → Jun 1987
Award Date: 30 Jun 1987
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Pass, Y. (Speaker)
Activity: Talk or presentation › Oral presentation
Pass, Y. (Keynote speaker)
Activity: Talk or presentation › Invited talk
Pass, Y. (Keynote speaker)
Activity: Talk or presentation › Invited talk
Pass, Y. (Invited speaker)
Activity: Talk or presentation › Invited talk
Pass, Y. (Keynote speaker)
Activity: Talk or presentation › Invited talk
Student thesis: Thesis