Research output per year
Research output per year
Personal profile
About Me
Senior Lecturer (Assistant Professor) Principal Investigator, Laboratory for Host-Microbiome Interactions.
The intestinal immune system and the microbiome: communication networks and decision-making processes
We study the cellular, molecular and genetic mechanisms that facilitate communication between cells of the immune system and their environment in the gut - the gut microbes (microbiome), the enteric nervous system, and intestinal epithelium, etc…
We aim to understand how these intercellular communication networks control immunological decision-making processes, between inflammation and immunological tolerance, in health and in autoimmune and chronic inflammatory diseases (such as inflammatory bowel diseases).
We combine microscopy, genomics and molecular biology together with a unique gut organ culture system, that allow dissecting these host-environment interactions in real-time, ex-vivo (Yissachar et al., Cell, 2017).
In addition, we combine principles of systems biology, to understand how cells of the immune system process environmental signals in real-time (Yissachar et al., Molecular Cell, 2013).
Education/Academic qualification
PhD, Bar-Ilan University
Oct 2004 → Sep 2008
Award Date: 30 Sep 2008
Master's Degree, Bar-Ilan University
Oct 2003 → Sep 2004
Award Date: 30 Sep 2004
Bachelor, Bar-Ilan University
Oct 2000 → Sep 2003
Award Date: 30 Sep 2003
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Collaborations and top research areas from the last five years
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Cell-autonomous innate immunity by proteasome-derived defence peptides
Goldberg, K., Lobov, A., Antonello, P., Shmueli, M. D., Yakir, I., Weizman, T., Ulman, A., Sheban, D., Laser, E., Kramer, M. P., Shteinvil, R., Chen, G., Ibraheem, A., Sysoeva, V., Fishbain-Yoskovitz, V., Mohapatra, G., Abramov, A., Shimshi, S., Ogneva, K. & Nandy, M. & 10 others, , 27 Mar 2025, In: Nature. 639, 8056, p. 1032-1041 10 p.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
From microbiota to menu: predicting individual responses to dietary components
Romano-Zadaka, H. & Yissachar, N., 8 Oct 2025, In: Gut. 74, 11, p. 1760-1762 3 p.Research output: Contribution to journal › Comment/debate
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Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation
Dürholz, K., Ehnes, L., Linnerbauer, M., Schmid, E., Danzer, H., Hinzpeter-Schmidt, M., Lößlein, L., Amend, L., Frech, M., Azizov, V., Schälter, F., Gessner, A., Lucas, S., Lesker, T. R., Taudte, R. V., Hofmann, J., Beyer, F., Bootz-Maoz, H., Reich, Y. & Romano, H. & 15 others, , 16 Sep 2025, In: Journal of Clinical Investigation. 135, 18, e184697.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis
Naim, G., Romano-Zadaka, H., Amidror, S., Jessula Levy, D., Cohen, A., Sochen, C., Gilberg, H., Farah, N., Rudenko, V., Yarden, Y., Feng, M., Tsentsarevsky, R., Brodie, Z., Reich, Y., Simon, A., Toister, E., Shoval, I., Armon, L., Schiller, M. & Mandel, Y. & 2 others, , 14 Nov 2025, In: Nature Communications. 16, 1, 10010.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Supplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson’s disease: a randomized double-blind prospective study
Hegelmaier, T., Duscha, A., Desel, C., Fuchs, S., Shapira, M., Amidror, S., Shan, Q., Stangl, G. I., Hirche, F., Kempa, S., Maifeld, A., Würtele, L. M., Peplinski, J., Jauk, D., Naim, G., Shidlovsky, N., Cohen, A., Bennet, Y., Paschold, L. & Dumitru, C. A. & 12 others, , 5 Dec 2025, In: Scientific Reports. 16, 1, 315.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations
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Departmental Seminar/Colloquium: Thinking outside the mouse: Ex-vivo dissections of host-microbiome cross talks
Yissachar, N. (Invited speaker)
2020 → …Activity: Talk or presentation › Oral presentation
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Departmental Seminar/Colloquium: Thinking outside the mouse: Ex-vivo dissections of host-microbiome cross talks
Yissachar, N. (Invited speaker)
2020 → …Activity: Talk or presentation › Oral presentation
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Departmental Seminar/Colloquium: Thinking outside the mouse: Ex-vivo dissections of host-microbiome cross talks
Yissachar, N. (Invited speaker)
2020 → …Activity: Talk or presentation › Oral presentation
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Conference Invited
Yissachar, N. (Invited speaker)
4 Nov 2019 → 5 Nov 2019Activity: Talk or presentation › Invited talk
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Departmental Seminar/Colloquium: Thinking outside the mouse: Ex-vivo dissections of host-microbiome cross talks
Yissachar, N. (Invited speaker)
2019 → …Activity: Talk or presentation › Oral presentation