Research output per year
Research output per year
Personal profile
About Me
Senior Lecturer (Assistant Professor) Principal Investigator, Laboratory for Host-Microbiome Interactions.
The intestinal immune system and the microbiome: communication networks and decision-making processes
We study the cellular, molecular and genetic mechanisms that facilitate communication between cells of the immune system and their environment in the gut - the gut microbes (microbiome), the enteric nervous system, and intestinal epithelium, etc…
We aim to understand how these intercellular communication networks control immunological decision-making processes, between inflammation and immunological tolerance, in health and in autoimmune and chronic inflammatory diseases (such as inflammatory bowel diseases).
We combine microscopy, genomics and molecular biology together with a unique gut organ culture system, that allow dissecting these host-environment interactions in real-time, ex-vivo (Yissachar et al., Cell, 2017).
In addition, we combine principles of systems biology, to understand how cells of the immune system process environmental signals in real-time (Yissachar et al., Molecular Cell, 2013).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
Dive into the research topics where Nissan Yissachar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics
Bootz-Maoz, H., Simon, A., Del Mare-Roumani, S., Bennet, Y., Toister, E., Romano, H., Zheng, D., Amidror, S., Elinav, E. & Yissachar, N., Dec 2023, In: npj Biofilms and Microbiomes. 9, 1, 44.Research output: Contribution to journal › Article › peer-review
Open Access -
Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome
Bootz-Maoz, H., Pearl, A., Melzer, E., Malnick, S., Sharon, E., Bennet, Y., Tsentsarevsky, R., Abuchatzera, S., Amidror, S., Aretz, E., Azriel, S., Gam Ze Letova, C., Naama, M., Shoval, I., Yaron, O., Karako-Lampert, S., Bel, S. & Yissachar, N., 15 Nov 2022, In: Cell Reports. 41, 7, 111657.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Regulation of Host Immunity by the Gut Microbiota
Partney, H. & Yissachar, N., 2022, Progress in Inflammation Research. Springer Nature, p. 105-140 36 p. (Progress in Inflammation Research; vol. 89).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
-
Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts
Sassone-Corsi, M., Azriel, S., Simon, A., Ramanan, D., Ortiz-Lopez, A., Chen, F., Yissachar, N., Mathis, D. & Benoist, C., 11 Oct 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 41, e2209624119.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics
Monzani, R., Gagliardi, M., Clemente, N., Saverio, V., Pańczyszyn, E., Santoro, C., Yissachar, N., Visciglia, A., Pane, M., Amoruso, A. & Corazzari, M., 27 Oct 2022, In: Biology. 11, 11, 1574.Research output: Contribution to journal › Article › peer-review
Open Access
-
Departmental Seminar/Colloquium: Thinking outside the mouse: Ex-vivo dissections of host-microbiome cross talks
Nissan Yissachar (Invited speaker)
2020 → …Activity: Talk or presentation › Oral presentation
-
Departmental Seminar/Colloquium: Thinking outside the mouse: Ex-vivo dissections of host-microbiome cross talks
Nissan Yissachar (Invited speaker)
2020 → …Activity: Talk or presentation › Oral presentation
-
Departmental Seminar/Colloquium: Thinking outside the mouse: Ex-vivo dissections of host-microbiome cross talks
Nissan Yissachar (Invited speaker)
2020 → …Activity: Talk or presentation › Oral presentation
-
Conference Invited
Nissan Yissachar (Invited speaker)
18 Feb 2019 → 19 Feb 2019Activity: Talk or presentation › Invited talk
-
Conference Invited
Nissan Yissachar (Invited speaker)
23 Sep 2019 → 25 Sep 2019Activity: Talk or presentation › Invited talk