he REBELab is a bioengineering lab developing advanced in vitro models, including organ-on-chip and organoids, to study human physiology and disease. We are especially interested in studying how tissues respond to cellular stress, and in the innate mechanisms that restore tissues function and homeostasis. By modeling human tissues and their interactions, we hope to improve our understanding of complex physiological systems, to identify new therapeutic approaches for a wide range of diseases and to enhance human performance.  

We use a wide range of tools, including material engineering, stem cells, cell biology, microscopy, proteomics and more.

The ongoing projects in the lab are diverse and include studies of how the vascular endothelium regulates tissue homeostasis via extracellular vesicles in normal physiology, and how these mechanisms are modulated in disease state like diabetes, aging and obesity.

We develop muscle-on-chip and Heart-on-chip models of degenerative muscle disease and myopathies.

And we engage in large scale tissue engineering projects to produce muscular tissue grafts and substitutes.