Personal profile

About Me

Hepatitis C virus (HCV) is a major cause of chronic liver disease and liver cancer with over 180 million persons infected worldwide. While some of the viral genes conform to the definition of oncogenes, the necessity of chronic infection for hepatocellular carcinoma to develop is currently unexplained. Moreover, no vaccine for HCV is available, and immunity against the virus is very poorly understood. Our Lab leads a research that will contribute to the rational vaccine design against HCV through exploring the antibody response to this infectious agent. We implement a comprehensive study that will fill the critically important gap in technology and knowledge related to the mechanisms of antibody-mediated neutralization of HCV. An important focus of this study will be to translate this information to characterize the envelope structure of the virus and to develop new vaccine strategies. In another line of research we aim to contribute to understanding the pathogenesis of HCV infection and its effect on the mechanisms leading to hepatocellular carcinoma (HCC). We study the dynamic evolutionary balance between the viral modulations of epigenetic changes of chromatin, the HCC-borne mutations, the viral genome and immune system. We also explore the processes that drives HCV infected hepatocytes towards becoming invasive and metastatic

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Tel Aviv University

Jan 2001Jan 2005

Award Date: 1 Jan 2005

Master's Degree, Tel Aviv University

Oct 1998Oct 2000

Award Date: 1 Oct 2000

Bachelor, Tel Aviv University

Oct 1995Oct 1998

Award Date: 1 Oct 1998

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Collaborations and top research areas from the last five years

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  • Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity

    Safra, M., Tamari, Z., Polak, P., Shiber, S., Matan, M., Karameh, H., Helviz, Y., Levy-Barda, A., Yahalom, V., Peretz, A., Ben-Chetrit, E., Brenner, B., Tuller, T., Gal-Tanamy, M. & Yaari, G., 2023, In: Frontiers in Immunology. 14, 1031914.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • High-Resolution Genomic Profiling of Liver Cancer Links Etiology With Mutation and Epigenetic Signatures

    Perez, S., Lavi-Itzkovitz, A., Gidoni, M., Domovitz, T., Dabour, R., Khurana, I., Davidovich, A., Tobar, A., Livoff, A., Solomonov, E., Maman, Y., El-Osta, A., Tsai, Y., Yu, M. L., Stemmer, S. M., Haviv, I., Yaari, G. & Gal-Tanamy, M., Jan 2023, In: CMGH. 16, 1, p. 63-81 19 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Joint statement in support of hepatitis C human challenge studies

    Alter, H. J., Barnes, E., Biondi, M. J., Cox, A. L., Eberts, J. D., Feld, J. J., Liang, T. J., Morrison, J., Rice, C. M., Shoukry, N. H., Thomas, D. L., Van Gennip, J., Weijer, C., Aghemo, A., Akiyama, M., Ali, M., Alter, H., Bader, R., Bailey, J. R. & Balaban, Y. & 111 others, Banerjee, S., Bartenschlager, R., Baumert, T. F., Berenguer, M., Bhadoria, A. S., Biondi, M., Bonanni, P., Bonella, A. E., Bruggmann, P., Bruneau, J., Bull, R. A., Butsashvili, M., Cahn, P., Caplan, A. L., Chappell, R. Y., Chisari, F., Chung, R., Cooke, G., Cox, A. L., Dalgard, O., Dao, D. Y., Darzi, A., Dieterich, D., Dillon, J. F., Dore, G. J., Doyle, J. S., Drummer, H. E., Durbin, A. P., Dusheiko, G., Eberts, J. D., Eyal, N., Feld, J., Ferguson, K., Flisiak, R., Forns, X., Foster, G. R., Foung, S., Gal-Tanamy, M., Gane, E., Gehring, A. J., George, J., Ghany, M. G., Gilbert, D. T., Glaze, K., Goodman, K. W., Grebely, J., Hamid, S., Haybron, D. M., Holton, R., Ignarro, L. J., Jackson, T., Jamieson, D., Jollimore, J., Karaba, A., Klein, M., Lauer, G., Law, M., Lemon, S. M., Liang, T. J., Liu, L., Lohmann, V., Mak, L. Y., Marinho, R. T., Marsh, A. A., Miller, L., Morrison, J., Negro, F., Nguyen, B. V., Page, K., Paterson, K., Pedrana, A., Pietschmann, T., Pinker, S., Plotkin, S., Ray, S. C., Reau, N., Remak, W. M., Rice, C. M., Ridruejo, E., Roberts, R. J., Roth, A., Rouphael, N., Sanders, R., Sandvold, R., Schafer, A., Schinkel, J., Seto, W. K., Shoukry, N., Singer, P., Solomon, S., Somerville, C., Sonderup, M. W., Sulkowski, M., Talaat, K., Temkin, L., Terrault, N., Thio, C., Thomas, D. L., Thompson, A. J., Tzarum, N., van der Valk, M., Waked, I., Walen, A., Walker, C. M., Wedemeyer, H., Wikler, D., Wilkinson, D., Youngs, H., Yuen, M. F., Zack, B. & Zinger, E., Nov 2023, In: The Lancet Gastroenterology and Hepatology. 8, 11, p. 967-969 3 p.

    Research output: Contribution to journalLetterpeer-review

    1 Scopus citations
  • Open Access
    9 Scopus citations
  • Autoimmune Disease Classification Based on PubMed Text Mining

    Samuels, H., Malov, M., Saha Detroja, T., Ben Zaken, K., Bloch, N., Gal-Tanamy, M., Avni, O., Polis, B. & Samson, A. O., 26 Jul 2022, In: Journal of Clinical Medicine. 11, 15, 4345.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    8 Scopus citations