Research output per year
Research output per year
Personal profile
About Me
The lab studies the genetic and cellular function of the brain. The lab main research interests are neurodevelopment and neuroendocrinology with special emphasis on sleep and sleep disorders. To understand these processes, we combine the use of genetic manipulations, real-time 2-photon imaging of single molecules, organelles, and neurons, as well as video-tracking of behavior in live zebrafish. The zebrafish is a simple vertebrate with evolutionary conserved organization of the central nervous system. This unique transparent model is amenable for live imaging and highthroughput genetic and pharmacological experiments.
Our general goal is to link gene function with the development and plasticity of neuronal circuits that regulate specific behavior. In order to understand human brain disorders, we develop several zebrafish models. The function of genes and neuronal circuits is determined using loss-of-function (CRISPR-mediated genome editing as well as genetic silencing and ablation of a specific neuronal population) and gain-of-function (transposon-mediated transgenesis, pharmacology and optogenetics) experiments.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Bar-Ilan University
Jan 2001 → Jan 2005
Award Date: 1 Jan 2005
Master's Degree, Bar-Ilan University
Jan 2000 → Jan 2001
Award Date: 1 Jan 2001
Bachelor, Bar-Ilan University
Jan 1997 → Jan 2000
Award Date: 1 Jan 2000
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues
Aguillon, R., Rinsky, M., Simon-Blecher, N., Doniger, T., Appelbaum, L. & Levy, O., 14 May 2024, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations
Sagi, D., Tibi, M., Admati, I., Lerer-Goldshtein, T., Hochgerner, H., Zeisel, A. & Appelbaum, L., 4 Sep 2024, In: Journal of Neuroscience. 44, 36, e0095242024.Research output: Contribution to journal › Article › peer-review
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Venom trade-off shapes interspecific interactions, physiology, and reproduction
Surm, J. M., Birch, S., Macrander, J., Jaimes-Becerra, A., Fridrich, A., Aharoni, R., Rozenblat, R., Sharabany, J., Appelbaum, L., Reitzel, A. M. & Moran, Y., 15 Mar 2024, In: Science advances. 10, 11, eadk3870.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Radial astrocyte synchronization modulates the visual system during behavioral-state transitions
Uribe-Arias, A., Rozenblat, R., Vinepinsky, E., Marachlian, E., Kulkarni, A., Zada, D., Privat, M., Topsakalian, D., Charpy, S., Candat, V., Nourin, S., Appelbaum, L. & Sumbre, G., 20 Dec 2023, In: Neuron. 111, 24, p. 4040-4057.e6Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System
Confino, S., Dor, T., Tovin, A., Wexler, Y., Livne, Z. B. M., Kolker, M., Pisanty, O., Park, S. K., Geyer, N., Reiter, J., Edvardson, S., Mor-Shaked, H., Elpeleg, O., Vallone, D., Appelbaum, L., Foulkes, N. S. & Gothilf, Y., 21 Feb 2022, In: International Journal of Molecular Sciences. 23, 4, 2373.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations
Activities
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Israel Society for Microscopy (External organization)
Appelbaum, L. (Member)
2018 → …Activity: Membership › Membership of association
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International Zebrafish Society (External organization)
Appelbaum, L. (Member)
2018 → …Activity: Membership › Membership of association
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Stanford University
Appelbaum, L. (Visiting researcher)
2 Dec 2016 → 2 Dec 2017Activity: Visiting an external institution › Visiting an external academic institution
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Conference Invited Keynote
Appelbaum, L. (Keynote speaker)
1 Jan 2016Activity: Talk or presentation › Invited talk
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Conference Invited Keynote
Appelbaum, L. (Keynote speaker)
1 Jan 2016Activity: Talk or presentation › Invited talk
Thesis
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Speciation processes and the establishment of zonation in Tetraclita in the Red Sea - The role of specific settlement and natural selection
APPELBAUM, L. (Author), Achituv, Y. (Supervisor) & Mokady, O. (Supervisor), 2001Student thesis: Thesis