Research output per year
Research output per year
Personal profile
About Me
The lab studies the genetic and cellular function of the brain. The lab main research interests are neurodevelopment and neuroendocrinology with special emphasis on sleep and sleep disorders. To understand these processes, we combine the use of genetic manipulations, real-time 2-photon imaging of single molecules, organelles, and neurons, as well as video-tracking of behavior in live zebrafish. The zebrafish is a simple vertebrate with evolutionary conserved organization of the central nervous system. This unique transparent model is amenable for live imaging and highthroughput genetic and pharmacological experiments.
Our general goal is to link gene function with the development and plasticity of neuronal circuits that regulate specific behavior. In order to understand human brain disorders, we develop several zebrafish models. The function of genes and neuronal circuits is determined using loss-of-function (CRISPR-mediated genome editing as well as genetic silencing and ablation of a specific neuronal population) and gain-of-function (transposon-mediated transgenesis, pharmacology and optogenetics) experiments.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System
Confino, S., Dor, T., Tovin, A., Wexler, Y., Livne, Z. B. M., Kolker, M., Pisanty, O., Park, S. K., Geyer, N., Reiter, J., Edvardson, S., Mor-Shaked, H., Elpeleg, O., Vallone, D., Appelbaum, L., Foulkes, N. S. & Gothilf, Y., 1 Feb 2022, In: International Journal of Molecular Sciences. 23, 4, 2373.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish
Rozenblat, R., Tovin, A., Zada, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T. & Appelbaum, L., 1 Mar 2022, In: International Journal of Molecular Sciences. 23, 5, 2464.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish
Wasserman-Bartov, T., Admati, I., Lebenthal-Loinger, I., Sharabany, J., Lerer-Goldshtein, T. & Appelbaum, L., 2 Nov 2022, In: Journal of Neuroscience. 42, 44, p. 8214-8224 11 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Flatfoot in Africa, the cirripede Chthamalus in the west Indian Ocean
Simon-Blecher, N., Jacob, A., Levy, O., Appelbaum, L., Elbaz-Ifrah, S. & Achituv, Y., 8 Jul 2021, In: PeerJ. 9, p. e11710 30 p., e11710.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Heterogeneity of Hypocretin/Orexin Neurons
Sagi, D., De Lecea, L. & Appelbaum, L., 2021, In: Frontiers of Neurology and Neuroscience. 45, p. 61-74 14 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations
Activities
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Israel Society for Microscopy (External organization)
Lior Appelbaum (Member)
2018 → …Activity: Membership › Membership of association
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International Zebrafish Society (External organization)
Lior Appelbaum (Member)
2018 → …Activity: Membership › Membership of association
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Stanford University
Lior Appelbaum (Visiting researcher)
2 Dec 2016 → 2 Dec 2017Activity: Visiting an external institution › Visiting an external academic institution
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Conference Invited Keynote
Lior Appelbaum (Keynote speaker)
1 Jan 2016Activity: Talk or presentation › Invited talk
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Conference Invited Keynote
Lior Appelbaum (Keynote speaker)
1 Jan 2016Activity: Talk or presentation › Invited talk
Thesis
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Speciation processes and the establishment of zonation in Tetraclita in the Red Sea - The role of specific settlement and natural selection
Author: APPELBAUM, L., 2001Supervisor: Achituv, Y. (External person) (Supervisor) & Mokady, O. (External person) (Supervisor)
Student thesis: Thesis