Research output per year
Research output per year
Personal profile
About Me
Prof. Doron Ginsberg, of Bar-Ilan’s Mina & Everard Goodman Faculty of Life Sciences, has been Dean of the Faculty since 2017. After completing his postdoctoral research at Harvard Medical School, Prof. Ginsberg joined the research staff at the Weizmann Institute of Science, where he had obtained his master’s and doctoral degrees under the supervision of Prof. Moshe Oren. He holds a bachelor’s degree in biology (with honors) from Tel Aviv University. In 2005, Prof. Ginsberg joined BIU’s Goodman Faculty of Life Sciences.
Prof. Ginsberg studies the control of cell growth and mortality and the disruption of these processes during the development of cancer. His research focuses on two key players in the control of cell proliferation and mortality: the E2F transcription factor and long non-coding RNA transcripts. Prof. Ginsberg has supervised 40 master, doctoral and postdoctoral students, and published 60 articles in professional journals and books.
Prof. Ginsberg has served over the years as a member of various university committees. He sat on the Supreme Appointments Committee and is a member of the Senate. In addition, he sat on the Professional National Committee for Biology of the Israeli Ministry of Education.
As Dean of Life Sciences, Prof. Ginsberg directs a faculty with 50 senior academic staff members who are leading 50 research groups on a variety of subjects, including cancer research, immunology, virology, microbiology, aging research, plant science, animal behavior, vision science, marine biology, computational biology, and more. Some 350 graduate and postdoctoral research students are in these research groups. Many academic staff members have joined the faculty over the past decade, following postdoctoral studies at the world’s leading research institutions, and the faculty has a young and dynamic character. The Goodman Faculty of Life Sciences has some 800 undergraduates in a wide range of study programs, including biotechnology, expanded life sciences, computational biology, optometry, and dual-major degrees such as biology and chemistry, biology and psychology, biology and neuroscience, and more.
Research:
The E2F family of transcription factors plays a critical role in the control of cell proliferation by regulating the timely expression of many genes required for cell cycle progression. E2F activity is essential for cell proliferation and its inhibition leads to cessation of cell growth. In normal cells, E2F is tightly regulated to prevent uncontrolled growth. In cancer cells, its regulation is often abrogated and most human tumors exhibit deregulated and hyperactive E2F leading to uncontrolled cell proliferation.
Transcriptional activation of cell-cycle-related genes is only one facet of E2F activity and one member of this family, E2F1, can also mediate apoptosis. Furthermore a recent study from our lab shows that E2F1 can also induce autophagy. In addition, our studies show that E2F1 can activate a number of major signal transduction pathways including the PI3K/AKT; MEK/ERK, and p38 MAPK pathways.
Work in our lab focuses on elucidation of the molecular mechanism that mediates the effects of E2F on cell fate and intracellular signaling.
Current research topics in our lab are:
- Studying the mechanisms by which E2F1 sensitizes cells to chemotherapeutic treatments.
- Studying the crosstalk between E2Fs and signal transduction pathways.
- Isolation and characterization of novel E2F-regulated genes that affect autophagy. Elucidating the role of E2Fs in the regulation of autophagy.
- Identification of novel molecular links between E2F1 and the tumor suppressor p53.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Weizmann Institute of Science
… → Jan 1992
Award Date: 1 Jan 1992
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Collaborations and top research areas from the last five years
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The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis
Kumar, V., Sabaté-Cadenas, X., Soni, I., Stern, E., Vias, C., Ginsberg, D., Romá-Mateo, C., Pulido, R., Dodel, M., Mardakheh, F. K., Shkumatava, A. & Shaulian, E., 21 May 2024, In: Oncogene. 43, 21, p. 1608-1619 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation
Baruch, E., Nizri-Megnaji, T., Berkowitz, O. & Ginsberg, D., 25 May 2021, In: Oncotarget. 12, 11, p. 1072-1082 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Erratum: The novel long non-coding RNA TALNEC2, regulates tumor cell growth and the stemness and radiation response of glioma stem cells (Oncotarget (2017) 8 (31785–31801) DOI: 10.18632/oncotarget.15991)
Brodie, S., Lee, H. K., Jiang, W., Cazacu, S., Xiang, C., Poisson, L. M., Datta, I., Kalkanis, S., Ginsberg, D. & Brodie, C., 2021, In: Oncotarget. 12, 26, p. 2546-2547 2 p.Research output: Contribution to journal › Comment/debate
Open Access3 Scopus citations -
Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation
Tretina, K., Haidar, M., Madsen-Bouterse, S. A., Sakura, T., Mfarrej, S., Fry, L., Chaussepied, M., Pain, A., Knowles, D. P., Nene, V. M., Ginsberg, D., Daubenberger, C. A., Bishop, R. P., Langsley, G. & Silva, J. C., 4 Mar 2020, In: Scientific Reports. 10, 1, 3982.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Abstract 3567: A novel E2F1-regulated lncRNA, XLOC000190, is required for S phase progression and cell proliferation
Ginsberg, D., Nizri-Megnaji, T. & Baruch, E., 1 Jul 2019, In: Cancer Research. 79, 13_Supplement, p. 3567 1 p.Research output: Contribution to journal › Article › peer-review
Prizes
Activities
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Departmental Seminar/Colloquium: E2F1-regulated long non-coding RNA modulate cell proliferation and cancer development
Ginsberg, D. (Speaker)
2016 → …Activity: Talk or presentation › Oral presentation
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System Biology of non-coding RNAs
Ginsberg, D. (Participation - Conference participant)
31 Dec 2015Activity: Participating in or organizing an event › Organizing a conference, workshop, ...
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The long and the short of non coding RNA
Ginsberg, D. (Participation - Conference participant)
13 Jun 2015 → 18 Jun 2015Activity: Participating in or organizing an event › Organizing a conference, workshop, ...
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ESF-EMBO Long Regulatory RNAs
Ginsberg, D. (Participation - Conference participant)
12 Sep 2014 → 17 Sep 2014Activity: Participating in or organizing an event › Organizing a conference, workshop, ...
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Non-coding RNA from basic mechanisms to cancer
Ginsberg, D. (Participation - Conference participant)
21 Jun 2014 → 24 Jun 2014Activity: Participating in or organizing an event › Organizing a conference, workshop, ...
Thesis
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Analysis of the promoter region of the p53 gene
Ginsberg, D. (Author), Oren, M. (Supervisor), 1987Student thesis: Thesis
Profiles
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Binyamin Knisbacher
- Bar-Ilan University - Faculty of Life Sciences, The Mina and Everard Goodman Faculty of Life Sciences - Senior Lecturer
Person: Post Doctorate, Academic