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Binyamin Knisbacher

 https://orcid.org/0000-0002-4962-9956
20132025

Research activity per year

Personal profile

About Me

Cancer Genomics and Immunogenomics 

The lab develops and applies computational tools to study DNA and RNA aberrations that drive cancer and how these produce novel therapeutic opportunities. The lab uses bioinformatics and machine learning methods to characterize alterations in cancer cells and advance precision medicine for cancer patients. Our expertise can be applied to any tumor type, but we have special interest in cancers arising from immune cells and specifically chronic lymphocytic leukemia (CLL), a common B-cell leukemia. Thus, on the intersection of cancer genomics and immunology, we study the relationship between cancerous and normal immune cells and use computational genomics to identify new targets for immunotherapy.

The lab is launching in October 2022! We are recruiting highly motivated individuals for all training stages – MSc, PhD and Postdocs. MDs or individuals from other fields with programming experience that are enthusiastic about bioinformatics are welcome to apply.

Education/Academic qualification

Bachelor, Bar-Ilan University

Oct 2008 → Jun 2012

Award Date: 30 Jun 2012

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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Collaborations and top research areas from the last five years

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  • Disease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms

    Nadeu, F., Shuai, S., Clot, G., Hilton, L. K., Diaz-Navarro, A., Martín, S., Royo, R., Baumann, T., Kulis, M., López-Oreja, I., Cossio, M., Lu, J., Ljungström, V., Young, E., Plevova, K., Knisbacher, B. A., Lin, Z., Hahn, C. K., Bousquets, P. & Alcoceba, M. & 50 others, González, M., Colado, E., Payer, Á. R., Aymerich, M., Terol, M. J., Rivas-Delgado, A., Enjuanes, A., Ruiz-Gaspà, S., Chatzikonstantinou, T., Hägerstrand, D., Jylhä, C., Skaftason, A., Mansouri, L., Stranska, K., Doubek, M., van Gastel-Mol, E. J., Davis, Z., Walewska, R., Scarfò, L., Trentin, L., Visentin, A., Parikh, S. A., Rabe, K. G., Moia, R., Armand, M., Rossi, D., Davi, F., Gaidano, G., Kay, N. E., Shanafelt, T. D., Ghia, P., Oscier, D., Langerak, A. W., Beà, S., López-Guillermo, A., Neuberg, D., Wu, C. J., Getz, G., Pospisilova, S., Stamatopoulos, K., Rosenquist, R., Huber, W., Zenz, T., Colomer, D., Martín-Subero, J. I., Delgado, J., Morin, R. D., Stein, L. D., Puente, X. S. & Campo, E., Sep 2025, In: Leukemia. 39, 9, p. 2076-2086 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • SplitFusion enables ultrasensitive gene fusion detection and reveals fusion variant-associated tumor heterogeneity

    Bian, W., Zhang, B., Song, Z., Knisbacher, B. A., Chan, Y. M., Bao, C., Xu, C., Wang, W., Chu, A. H. Y., Lu, C., Wang, H., Bao, S., Gong, Z., Keung, H. Y., Chow, Z. Y. M., Zhang, Y., Cheuk, W., Getz, G., Nardi, V. & Yang, M. & 4 others, Cho, W. C. S., Wang, J., Chen, J. & Zheng, Z., 14 Feb 2025, In: Patterns. 6, 2, 101174.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations

  • Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia

    Vijenthira, A., Volpe, V. O., Sekar, A., Azevedo, R. S., Mikhaleva, M., Gibson, C. J., Martindale, S. P., Fardoun, R., Tyekucheva, S., Ren, Y., Fernandes, S. M., Knisbacher, B. A., Hahn, C. K., Getz, G., Wu, C. J., Davids, M. S. & Brown, J. R., 10 Dec 2024, In: Blood advances. 8, 23, p. 5949-5956 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

    Parry, E. M., Leshchiner, I., Guièze, R., Johnson, C., Tausch, E., Parikh, S. A., Lemvigh, C., Broséus, J., Hergalant, S., Messer, C., Utro, F., Levovitz, C., Rhrissorrakrai, K., Li, L., Rosebrock, D., Yin, S., Deng, S., Slowik, K., Jacobs, R. & Huang, T. & 34 others, Li, S., Fell, G., Redd, R., Lin, Z., Knisbacher, B. A., Livitz, D., Schneider, C., Ruthen, N., Elagina, L., Taylor-Weiner, A., Persaud, B., Martinez, A., Fernandes, S. M., Purroy, N., Anandappa, A. J., Ma, J., Hess, J., Rassenti, L. Z., Kipps, T. J., Jain, N., Wierda, W., Cymbalista, F., Feugier, P., Kay, N. E., Livak, K. J., Danysh, B. P., Stewart, C., Neuberg, D., Davids, M. S., Brown, J. R., Parida, L., Stilgenbauer, S., Getz, G. & Wu, C. J., Jan 2023, In: Nature Medicine. 29, 1, p. 158-169 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    80 Scopus citations

  • IGLV3-21R110 mutation has prognostic value in patients with treatment-naive chronic lymphocytic leukemia

    Syrykh, C., Pons-Brun, B., Russiñol, N., Playa-Albinyana, H., Baumann, T., Duran-Ferrer, M., Kulis, M., Carbó-Meix, A., Mozas, P., Alcoceba, M., González, M., Navarro-Bailón, A., Colado, E., Payer, Á. R., Aymerich, M., Terol, M. J., Lu, J., Knisbacher, B. A., Hahn, C. K. & Ruiz-Gaspà, S. & 10 others, Enjuanes, A., Wu, C. J., Getz, G., Zenz, T., López-Guillermo, A., Martín-Subero, J. I., Colomer, D., Delgado, J., Campo, E. & Nadeu, F., 12 Dec 2023, In: Blood advances. 7, 23, p. 7384-7391 8 p.

    Research output: Contribution to journal › Letter › peer-review

    Open Access
    8 Scopus citations
View all 24 Research outputs