Binyamin Knisbacher

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Binyamin Knisbacher

 https://orcid.org/0000-0002-4962-9956
20132023

Research activity per year

Personal profile

About Me

Cancer Genomics and Immunogenomics 

The lab develops and applies computational tools to study DNA and RNA aberrations that drive cancer and how these produce novel therapeutic opportunities. The lab uses bioinformatics and machine learning methods to characterize alterations in cancer cells and advance precision medicine for cancer patients. Our expertise can be applied to any tumor type, but we have special interest in cancers arising from immune cells and specifically chronic lymphocytic leukemia (CLL), a common B-cell leukemia. Thus, on the intersection of cancer genomics and immunology, we study the relationship between cancerous and normal immune cells and use computational genomics to identify new targets for immunotherapy.

The lab is launching in October 2022! We are recruiting highly motivated individuals for all training stages – MSc, PhD and Postdocs. MDs or individuals from other fields with programming experience that are enthusiastic about bioinformatics are welcome to apply.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Bachelor, Bar-Ilan University

Oct 2008 → Jun 2012

Award Date: 30 Jun 2012

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Collaborations and top research areas from the last five years

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  • Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

    Parry, E. M., Leshchiner, I., Guièze, R., Johnson, C., Tausch, E., Parikh, S. A., Lemvigh, C., Broséus, J., Hergalant, S., Messer, C., Utro, F., Levovitz, C., Rhrissorrakrai, K., Li, L., Rosebrock, D., Yin, S., Deng, S., Slowik, K., Jacobs, R. & Huang, T. & 34 others, Li, S., Fell, G., Redd, R., Lin, Z., Knisbacher, B. A., Livitz, D., Schneider, C., Ruthen, N., Elagina, L., Taylor-Weiner, A., Persaud, B., Martinez, A., Fernandes, S. M., Purroy, N., Anandappa, A. J., Ma, J., Hess, J., Rassenti, L. Z., Kipps, T. J., Jain, N., Wierda, W., Cymbalista, F., Feugier, P., Kay, N. E., Livak, K. J., Danysh, B. P., Stewart, C., Neuberg, D., Davids, M. S., Brown, J. R., Parida, L., Stilgenbauer, S., Getz, G. & Wu, C. J., Jan 2023, In: Nature Medicine. 29, 1, p. 158-169 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • IGLV3-21R110 mutation has prognostic value in patients with treatment-naive chronic lymphocytic leukemia

    Syrykh, C., Pons-Brun, B., Russiñol, N., Playa-Albinyana, H., Baumann, T., Duran-Ferrer, M., Kulis, M., Carbó-Meix, A., Mozas, P., Alcoceba, M., González, M., Navarro-Bailón, A., Colado, E., Payer, Á. R., Aymerich, M., Terol, M. J., Lu, J., Knisbacher, B. A., Hahn, C. K. & Ruiz-Gaspà, S. & 10 others, Enjuanes, A., Wu, C. J., Getz, G., Zenz, T., López-Guillermo, A., Martín-Subero, J. I., Colomer, D., Delgado, J., Campo, E. & Nadeu, F., 12 Dec 2023, In: Blood advances. 7, 23, p. 7384-7391 8 p.

    Research output: Contribution to journal › Letter › peer-review

    Open Access
    2 Scopus citations

  • In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities

    ten Hacken, E., Sewastianik, T., Yin, S., Hoffmann, G. B., Gruber, M., Clement, K., Penter, L., Redd, R. A., Ruthen, N., Hergalant, S., Sholokhova, A., Fell, G., Parry, E. M., Broséus, J., Guieze, R., Lucas, F., Hernández-Sánchez, M., Baranowski, K., Southard, J. & Joyal, H. & 20 others, Billington, L., Regis, F. F. D., Witten, E., Uduman, M., Knisbacher, B. A., Li, S., Lyu, H., Vaisitti, T., Deaglio, S., Inghirami, G., Feugier, P., Stilgenbauer, S., Tausch, E., Davids, M. S., Getz, G., Livak, K. J., Bozic, I., Neuberg, D. S., Carrasco, R. D. & Wu, C. J., 1 Mar 2023, In: Blood cancer discovery. 4, 2, p. 150-169 20 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome

    Parry, E. M., Lemvigh, C. K., Deng, S., Dangle, N., Ruthen, N., Knisbacher, B. A., Broséus, J., Hergalant, S., Guièze, R., Li, S., Zhang, W., Johnson, C., Long, J. M., Yin, S., Werner, L., Anandappa, A., Purroy, N., Gohil, S., Oliveira, G. & Bachireddy, P. & 15 others, Shukla, S. A., Huang, T., Khoury, J. D., Thakral, B., Dickinson, M., Tam, C., Livak, K. J., Getz, G., Neuberg, D., Feugier, P., Kharchenko, P., Wierda, W., Olsen, L. R., Jain, N. & Wu, C. J., 9 Oct 2023, In: Cancer Cell. 41, 10, p. 1803-1816.e8

    Research output: Contribution to journal › Article › peer-review

    6 Scopus citations

  • Molecular map of chronic lymphocytic leukemia and its impact on outcome

    Knisbacher, B. A., Lin, Z., Hahn, C. K., Nadeu, F., Duran-Ferrer, M., Stevenson, K. E., Tausch, E., Delgado, J., Barbera-Mourelle, A., Taylor-Weiner, A., Bousquets-Muñoz, P., Diaz-Navarro, A., Dunford, A., Anand, S., Kretzmer, H., Gutierrez-Abril, J., López-Tamargo, S., Fernandes, S. M., Sun, C. & Sivina, M. & 19 others, Rassenti, L. Z., Schneider, C., Li, S., Parida, L., Meissner, A., Aguet, F., Burger, J. A., Wiestner, A., Kipps, T. J., Brown, J. R., Hallek, M., Stewart, C., Neuberg, D. S., Martín-Subero, J. I., Puente, X. S., Stilgenbauer, S., Wu, C. J., Campo, E. & Getz, G., Nov 2022, In: Nature Genetics. 54, 11, p. 1664-1674 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    66 Scopus citations
View all 21 Research outputs