Anatoly Belostotskii

Structure, synthesis and drug-oriented design of small biomolecules are in the scope of my research. In structural studies, computational chemistry is main methodology, and my focus there has shifted from modeling of conformational dynamics to conformational analysis by means of a new (for synthetic chemists) tool in structure determination – QM-calculated chemical shifts. In synthetic studies, my main targets are DNA components, and my chemistry includes rational modifications of nucleoside structure in order to “equip” new nucleoside derivatives with a potent antiretroviral or anticancer activity. The goal chemical structures are prompted by my original design concepts; examples of the latter are agent-induced post-transriptional disruption of the nucleic acid chain and carbohydrate-mediated cryodeprotection.